人体血液与牙龈炎症性多形核白细胞的功能比较
A functional comparison of blood and gingival inflammatory polymorphonuclear leucocytes in man.
作者信息
Wilton J M, Renggli H H, Lehner T
出版信息
Clin Exp Immunol. 1977 Jan;27(1):152-8.
Abstract
Polymorphonuclear leucocytes from the human gingival crevice (CREV-PMN) have a defective phagocytic capacity when compared with peripheral blood polymorphonuclear leucocytes (PB-PMN) from the same individual. In a study of fourteen clinically healthy subjects, significantly smaller numbers of CREV-PMN phagocytosed fewer Candida albicans blastospores as compared with PB-PMN. The intracellularkilling capacity of the two cell populations was similar. Removal of specific antibody but not complement significantly depressed blastospore uptake by both cell types. It is postulated that the intrinsic defect of the CREV-PMN is acquired in vivo and may be a general property of PMN from inflammatory sites.
摘要
与来自同一个体的外周血多形核白细胞（PB-PMN）相比，人牙龈沟多形核白细胞（CREV-PMN）具有缺陷的吞噬能力。在一项针对14名临床健康受试者的研究中，与PB-PMN相比，CREV-PMN吞噬白色念珠菌芽生孢子的数量明显更少，且吞噬的芽生孢子数量也显著更少。这两种细胞群体的细胞内杀伤能力相似。去除特异性抗体而非补体，会显著降低两种细胞类型对芽生孢子的摄取。据推测，CREV-PMN的内在缺陷是在体内获得的，可能是炎症部位PMN的普遍特性。
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