左旋咪唑与人类淋巴细胞表面标志物
Levamisole and human lymphocyte surface markers.
作者信息
Wybran J, Govaerts A
出版信息
Clin Exp Immunol. 1977 Feb;27(2):319-21.
The action of various concentrations of levamisole on normal human lymphocytes was investigated in vitro. The action of levamisole (10(-1) mg-10(-8) mg%) upon rosette formation was studied using two rosette assays with SRBC (the active and the total T-rosette tests) to quantify T cells and the EAC assay to quantify B cells. Levamisole at only 10(-3) mg% significantly increased the percentage of both active and total T cells. In sharp contrast, levamisole between 10(-2) and 10(-7) mg% significantly decreased the EAC percentage. It is concluded that levamisole promotes a better expressivity of T-cell receptor and decreases the expressivity of C3 receptor.
在体外研究了不同浓度的左旋咪唑对正常人淋巴细胞的作用。使用两种含绵羊红细胞的玫瑰花结试验（活性T细胞玫瑰花结试验和总T细胞玫瑰花结试验）来定量T细胞，以及使用EAC试验来定量B细胞，研究了左旋咪唑（10⁻¹mg - 10⁻⁸mg%）对玫瑰花结形成的作用。仅10⁻³mg%的左旋咪唑显著增加了活性T细胞和总T细胞的百分比。形成鲜明对比的是，10⁻²至10⁻⁷mg%之间的左旋咪唑显著降低了EAC百分比。得出的结论是，左旋咪唑可促进T细胞受体更好地表达，并降低C3受体的表达。
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