Hu Qian, Peng Ze, Li Lingli, Zou Xin, Xu Lijun, Gong Jing, Yi Ping
Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Pharmacol. 2020 Feb 4;10:1694. doi: 10.3389/fphar.2019.01694. eCollection 2019.
Berberine-containing quadruple therapy (adding berberine to the standard triple therapy) is being used to treat infection, but the effects in randomized controlled trials (RCTs) are still controversial. Therefore, a meta-analysis is needed to estimate the efficacy and safety of berberine-containing quadruple therapy on eradication.
Ten databases were searched to find the available literature. RCTs about the efficacy and safety of berberine-containing quadruple therapy on eradication were included. The data of eradication rate, peptic ulcer healing rate, relieving rate of clinical symptoms and adverse events were extracted to appraise the net change with a fixed or randomized effect model.
A total of 13 articles were included in the analysis. Pooled results showed that the addition of berberine in standard triple therapy significantly improved eradication rate (RR 1.22; 95% CI 1.16 to 1.27; I = 12%), increased the peptic ulcer healing rate (RR 1.15; 95% CI 1.10 to 1.19; I = 44%), relieved the clinical symptoms (RR 1.11; 95% CI 1.06 to 1.17; I = 44%) and reduced the incidence of side events (RR 0.65; 95% CI 0.53 to 0.80; I = 58%) comparing to the standard triple therapy.
The analysis showed that the addition of berberine in standard triple therapy could improve eradication rate and clinical symptom remission rate, accelerate ulcer healing, and reduce adverse events, which is very beneficial to clinical work in China.
含小檗碱的四联疗法（在标准三联疗法基础上加用小檗碱）正用于治疗感染，但随机对照试验（RCT）中的效果仍存在争议。因此，需要进行一项荟萃分析来评估含小檗碱的四联疗法根除[幽门螺杆菌]的疗效和安全性。
检索十个数据库以查找可用文献。纳入关于含小檗碱的四联疗法根除[幽门螺杆菌]疗效和安全性的随机对照试验。提取根除率、消化性溃疡愈合率、临床症状缓解率及不良事件的数据，采用固定效应或随机效应模型评估净变化。
分析共纳入13篇文章。汇总结果显示，在标准三联疗法中加用小檗碱可显著提高根除率（RR 1.22；95%CI 1.16至1.27；I² = 12%），提高消化性溃疡愈合率（RR 1.15；95%CI 1.10至1.19；I² = 44%），缓解临床症状（RR 1.11；95%CI 1.06至1.17；I² = 44%），并降低不良事件发生率（RR 0.65；95%CI 0.53至0.80；I² = 58%），与标准三联疗法相比。
分析表明，在标准三联疗法中加用小檗碱可提高根除率和临床症状缓解率，加速溃疡愈合，并减少不良事件，这对中国的临床工作非常有益。
