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肿瘤微环境中的代谢：单细胞分析的见解

Metabolism in the tumor microenvironment: insights from single-cell analysis.

作者信息

Xiao Zhengtao, Locasale Jason W, Dai Ziwei

机构信息

Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.

Mainline Station Drive, Morrisville, NC, USA.

出版信息

Oncoimmunology. 2020 Feb 9;9(1):1726556. doi: 10.1080/2162402X.2020.1726556. eCollection 2020.

DOI:10.1080/2162402X.2020.1726556
PMID:32117592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7028342/
Abstract

The metabolism of both cancer and immune cells in the tumor microenvironment (TME) is poorly understood since most studies have focused on analysis in bulk samples and cell culture models. Our recent analyses of single-cell RNA sequencing data suggest that the metabolic features of single cells within TME differ greatly from those of the bulk measurements. Here, we discuss some key findings about metabolism in cancer and immune cells and discuss possible relevance to immunotherapy.

摘要

由于大多数研究都集中在对大量样本和细胞培养模型的分析上，因此对肿瘤微环境（TME）中癌细胞和免疫细胞的代谢了解甚少。我们最近对单细胞RNA测序数据的分析表明，TME内单细胞的代谢特征与大量测量的代谢特征有很大差异。在这里，我们讨论了一些关于癌细胞和免疫细胞代谢的关键发现，并讨论了其与免疫治疗可能的相关性。