Tianjin Key Laboratory of Pulp and Paper, Tianjin University of Science and Technology, Tianjin 300457, China.
Jiangxi Academy of Forestry, Nanchang 33032, China.
Curr Med Chem. 2020;27(28):4622-4646. doi: 10.2174/0929867327666200303102859.
Cellulose Nanofibrils (CNFs) are natural nanomaterials with nanometer dimensions. Compared with ordinary cellulose, CNFs own good mechanical properties, large specific surface areas, high Young's modulus, strong hydrophilicity and other distinguishing characteristics, which make them widely used in many fields. This review aims to introduce the preparation of CNFs-based hydrogels and their recent biomedical application advances.
By searching the recent literatures, we have summarized the preparation methods of CNFs, including mechanical methods and chemical mechanical methods, and also introduced the fabrication methods of CNFs-based hydrogels, including CNFs cross-linked with metal ion and with polymers. In addition, we have summarized the biomedical applications of CNFs-based hydrogels, including scaffold materials and wound dressings.
CNFs-based hydrogels are new types of materials that are non-toxic and display a certain mechanical strength. In the tissue scaffold application, they can provide a micro-environment for the damaged tissue to repair and regenerate it. In wound dressing applications, it can fit the wound surface and protect the wound from the external environment, thereby effectively promoting the healing of skin tissue.
By summarizing the preparation and application of CNFs-based hydrogels, we have analyzed and forecasted their development trends. At present, the research of CNFs-based hydrogels is still in the laboratory stage. It needs further exploration to be applied in practice. The development of medical hydrogels with high mechanical properties and biocompatibility still poses significant challenges.
纤维素纳米纤维（CNFs）是具有纳米尺寸的天然纳米材料。与普通纤维素相比，CNFs 具有良好的机械性能、大的比表面积、高的杨氏模量、强的亲水性等显著特点，使其在许多领域得到了广泛的应用。本综述旨在介绍 CNFs 基水凝胶的制备及其在最近生物医学应用中的进展。
通过检索最近的文献，我们总结了 CNFs 的制备方法，包括机械方法和化学机械方法，并介绍了 CNFs 基水凝胶的制备方法，包括 CNFs 与金属离子交联和与聚合物交联。此外，我们还总结了 CNFs 基水凝胶在生物医学中的应用，包括支架材料和伤口敷料。
CNFs 基水凝胶是一种新型的无毒材料，具有一定的机械强度。在组织支架应用中，它可以为受损组织提供一个修复和再生的微环境。在伤口敷料应用中，它可以贴合伤口表面，保护伤口免受外部环境的影响，从而有效促进皮肤组织的愈合。
通过总结 CNFs 基水凝胶的制备和应用，我们分析和预测了它们的发展趋势。目前，CNFs 基水凝胶的研究仍处于实验室阶段，需要进一步的探索才能应用于实际中。开发具有高机械性能和生物相容性的医用水凝胶仍然面临着重大挑战。
