Liu Y T, Jin C, Chen Z, Cai S X, Yin S N, Li G L, Watanabe T, Nakatsuka H, Seiji K, Inoue O
Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing.
Tohoku J Exp Med. 1988 Jun;155(2):183-95. doi: 10.1620/tjem.155.183.
Over 100 workers exposed to trichloroethylene (TRI) mostly at less than 50 ppm during the production or vapor degreasing operation and about an equal number of the non-exposed control workers were examined for subjective symptoms, hematology, serum biochemistry, and sugar, protein and occult blood in urine. Essentially all the clinico-laboratory tests stayed normal, and there was no significant differences in the findings between the exposed and the controls. Thus, no clinically significant effects of TRI exposure were found in the blood and liver functions among the exposed workers as compared with the controls. The prevalence of the subjective symptoms was, however, significantly higher in the exposed group than in the controls, and dose-response relationship could be established in some selected symptoms such as nausea, heavy feeling in the head, forgetfulness, tremor in extremities, cramp in extremities and dry mouth, although the exposure was low. The findings warrant further attention to the effects of TRI especially on the central nervous system at the concentration lower than e.g., 50 ppm.
100多名主要在生产或蒸汽脱脂操作中接触三氯乙烯（TRI）且接触浓度大多低于50 ppm的工人，以及数量大致相同的未接触的对照工人，接受了主观症状、血液学、血清生物化学以及尿液中的糖、蛋白质和潜血检查。基本上所有临床实验室检查结果均保持正常，接触组和对照组的检查结果没有显著差异。因此，与对照组相比，未发现接触TRI对接触工人的血液和肝功能有临床上显著的影响。然而，接触组主观症状的患病率显著高于对照组，并且在一些选定的症状如恶心、头部沉重感、健忘、肢体震颤、肢体痉挛和口干等方面可以建立剂量反应关系，尽管接触水平较低。这些发现值得进一步关注TRI在低于例如50 ppm的浓度下对中枢神经系统的影响。
