Yilmaz Elif Nur, Zeugolis Dimitrios I
Regenerative, Modular & Developmental Engineering Laboratory, National University of Ireland Galway, Galway, Ireland.
Science Foundation Ireland, Centre for Research in Medical Devices, National University of Ireland Galway, Galway, Ireland.
Front Bioeng Biotechnol. 2020 Feb 18;8:77. doi: 10.3389/fbioe.2020.00077. eCollection 2020.
Articular cartilage defects remain a clinical challenge. Articular cartilage defects progress to osteoarthritis, which negatively (e.g., remarkable pain, decreased mobility, distress) affects millions of people worldwide and is associated with excessive healthcare costs. Surgical procedures and cell-based therapies have failed to deliver a functional therapy. To this end, tissue engineering therapies provide a promise to deliver a functional cartilage substitute. Among the various scaffold fabrication technologies available, electrospinning is continuously gaining pace, as it can produce nano- to micro- fibrous scaffolds that imitate architectural features of native extracellular matrix supramolecular assemblies and can deliver variable cell populations and bioactive molecules. Herein, we comprehensively review advancements and shortfalls of various electrospun scaffolds in cartilage engineering.
关节软骨缺损仍然是一个临床挑战。关节软骨缺损会发展为骨关节炎，这对全球数百万人产生负面影响（例如，剧烈疼痛、活动能力下降、痛苦），并导致医疗费用过高。手术程序和基于细胞的疗法都未能提供有效的治疗方法。为此，组织工程疗法有望提供功能性软骨替代物。在现有的各种支架制造技术中，静电纺丝技术的应用越来越广泛，因为它可以生产出纳米到微米级的纤维支架，模仿天然细胞外基质超分子组装体的结构特征，并能搭载不同的细胞群体和生物活性分子。在此，我们全面综述了各种静电纺丝支架在软骨工程中的进展和不足。
