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子宫重塑中的免疫细胞：它们是内分泌干扰化学物质的靶标吗？

Immune Cells in the Uterine Remodeling: Are They the Target of Endocrine Disrupting Chemicals?

机构信息

Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University, Magdeburg, Germany.

出版信息

Front Immunol. 2020 Feb 19;11:246. doi: 10.3389/fimmu.2020.00246. eCollection 2020.

DOI:10.3389/fimmu.2020.00246
PMID:32140155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7043066/
Abstract

Sufficient uterine remodeling is essential for fetal survival and development. Pathologies related to poor remodeling have a negative impact on maternal and fetal health even years after birth. Research of the last decades yielded excellent studies demonstrating the key role of immune cells in the remodeling processes. This review summarizes the current knowledge about the relevance of immune cells for uterine remodeling during pregnancy and further discusses immunomodulatory effects of man-made endocrine disrupting chemicals on immune cells.

摘要

充分的子宫重塑对于胎儿的生存和发育至关重要。与重塑不良相关的病理情况即使在出生多年后也会对母婴健康产生负面影响。过去几十年的研究取得了出色的研究成果，这些研究表明免疫细胞在重塑过程中起着关键作用。本文总结了目前关于免疫细胞在妊娠期间子宫重塑中的相关性的知识，并进一步讨论了人为内分泌干扰化学物质对免疫细胞的免疫调节作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f0/7043066/af40fe17c5c7/fimmu-11-00246-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f0/7043066/af40fe17c5c7/fimmu-11-00246-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c8f0/7043066/af40fe17c5c7/fimmu-11-00246-g0001.jpg

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Association of Thyroid Function Test Abnormalities and Thyroid Autoimmunity With Preterm Birth: A Systematic Review and Meta-analysis.甲状腺功能测试异常和甲状腺自身免疫与早产的关联：系统评价和荟萃分析。
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