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健康母乳喂养婴儿在 2、6 和 12 周龄时母乳低聚糖与粪便微生物群的关联。

The association between breastmilk oligosaccharides and faecal microbiota in healthy breastfed infants at two, six, and twelve weeks of age.

机构信息

Laboratory of Microbiology, Wageningen University & Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.

Laboratory of Food Chemistry, Wageningen University & Research, Bornse Weilanden 9, 6708 WG, Wageningen, The Netherlands.

出版信息

Sci Rep. 2020 Mar 6;10(1):4270. doi: 10.1038/s41598-020-61024-z.

DOI:10.1038/s41598-020-61024-z
PMID:32144305
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7060319/
Abstract

Several factors affect gut microbiota development in early life, among which breastfeeding plays a key role. We followed 24 mother-infant pairs to investigate the associations between concentrations of selected human milk oligosaccharides (HMOs) in breastmilk, infant faeces, and the faecal microbiota composition in healthy, breastfed infants at two, six and 12 weeks of age. Lactation duration had a significant effect on breastmilk HMO content, which decreased with time, except for 3-fucosyllactose (3FL) and Lacto-N-fucopentaose III (LNFP III). We confirmed that microbiota composition was strongly influenced by infant age and was associated with mode of delivery and breastmilk LNFP III concentration at two weeks, with infant sex, delivery mode, and concentrations of 3'sialyllactose (3'SL) in milk at six weeks, and infant sex and Lacto-N-hexaose (LNH) in milk at 12 weeks of age. Correlations between levels of individual breastmilk HMOs and relative abundance of OTUs found in infant faeces, including the most predominant Bifidobacterium OTUs, were weak and varied with age. The faecal concentration of HMOs decreased with age and were strongly and negatively correlated with relative abundance of OTUs within genera Bifidobacterium, Parabacteroides, Escherichia-Shigella, Bacteroides, Actinomyces, Veillonella, Lachnospiraceae Incertae Sedis, and Erysipelotrichaceae Incertae Sedis, indicating the likely importance of these taxa for HMO metabolism in vivo.

摘要

有几个因素会影响婴儿早期的肠道微生物群发育，其中母乳喂养起着关键作用。我们跟踪了 24 对母婴对，以研究健康母乳喂养婴儿在 2、6 和 12 周时母乳中选定人乳寡糖（HMO）浓度与粪便微生物群组成之间的关系。哺乳期时间对母乳 HMO 含量有显著影响，除了 3-岩藻糖基乳糖（3FL）和乳-N-岩藻五糖 III（LNFP III）外，HMO 含量随时间而降低。我们证实，微生物群组成受婴儿年龄的强烈影响，并与分娩方式和两周时母乳 LNFP III 浓度相关，与婴儿性别、分娩方式和 6 周时乳中 3'-唾液酸乳糖（3'SL）浓度相关，以及婴儿性别和 12 周时乳中乳-N-己六糖（LNH）浓度相关。婴儿粪便中个体母乳 HMO 水平与粪便中发现的 OTU 的相对丰度之间的相关性较弱，且随年龄而变化。HMO 的粪便浓度随年龄而降低，与双歧杆菌属、副拟杆菌属、大肠杆菌-志贺氏菌属、拟杆菌属、放线菌属、韦荣球菌属、未确定地位的赖氨酰普雷沃氏菌科和未确定地位的埃希氏菌科属内 OTU 的相对丰度呈强烈负相关，表明这些分类群可能对体内 HMO 代谢很重要。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0576/7060319/d738109e45ea/41598_2020_61024_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0576/7060319/5173e513412f/41598_2020_61024_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0576/7060319/171f8a82f323/41598_2020_61024_Fig2_HTML.jpg
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