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睡眠时间、日照时间与血清 25-羟维生素 D 状况的关系:一项横断面研究。

Relationship between Sleep Duration, Sun Exposure, and Serum 25-Hydroxyvitamin D Status: A Cross-sectional Study.

机构信息

Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon, Republic of Korea.

Department of Statistics, Graduate School of Chung-Ang University, Seoul, Republic of Korea.

出版信息

Sci Rep. 2020 Mar 6;10(1):4168. doi: 10.1038/s41598-020-61061-8.

Abstract

Normal-range sleep duration is an important factor for general health and metabolism, and insufficient or excessive sleep is associated with chronic metabolic disease. Among the many factors that affect sleep duration, sun exposure plays an important role in maintaining regular circadian rhythm and is also involved in the production and activation of 25-hydroxyvitamin D [25(OH)D], which regulates various functions in the body. However, 25(OH)D is available through food and various nutritional supplements without sun exposure, so it is important to find out the complex relationship among sun exposure, vitamin D status, and sleep duration. The relationship between sun exposure, vitamin D status, and sleep duration was analyzed in the nationwide survey and examination of 25,534 study populations, after adjusting for demographic characteristics, physical characteristics, lifestyle status, and socio-demographic variables. Vitamin D status alone did not show the relationship with sleep duration, although there were statistical relationships in the various factors including sun exposure with sleep duration. There was a statistical difference in 25(OH)D according to sleep duration, only in low sun exposure group. Subjects with low sun exposure and excessive sleep duration comparatively lower 25(OH)D than those with normal-range sleep, even after adjustment for potentially confounding factors. Individuals with limited exposure to sunlight should maintain adequate vitamin D status to have an appropriate sleep duration for health.

摘要

正常的睡眠时长是整体健康和新陈代谢的重要因素,而睡眠不足或过多都与慢性代谢性疾病有关。在影响睡眠时长的诸多因素中,阳光照射对维持正常的昼夜节律起着重要作用,它还参与了 25-羟维生素 D[25(OH)D]的产生和激活,而后者可调节体内的各种功能。然而,25(OH)D 可通过食物和各种营养补充剂获得,而无需阳光照射,因此,了解阳光照射、维生素 D 状态和睡眠时长之间的复杂关系非常重要。在对 25534 名研究人群进行的全国性调查和检查中,调整了人口统计学特征、身体特征、生活方式状况和社会人口统计学变量后,分析了阳光照射、维生素 D 状态和睡眠时长之间的关系。单独的维生素 D 状态与睡眠时长没有关系,尽管在包括阳光照射在内的各种因素与睡眠时长之间存在统计学关系。只有在低阳光暴露组中,25(OH)D 根据睡眠时长存在统计学差异。与正常睡眠时长相比,低阳光暴露和睡眠时间过长的受试者 25(OH)D 水平较低,即使在调整了潜在的混杂因素后也是如此。阳光照射有限的个体应保持充足的维生素 D 状态,以获得健康所需的适当睡眠时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a15/7060268/4d0ee4bcc292/41598_2020_61061_Fig1_HTML.jpg

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