基于三蝶烯和席夫碱连接的多孔网络：高效气体吸收、高CO/N选择性及优异的抗增殖活性
Triptycene-Based and Schiff-Base-Linked Porous Networks: Efficient Gas Uptake, High CO/N Selectivity, and Excellent Antiproliferative Activity.
作者信息
Alam Akhtar, Mishra Snehasis, Hassan Atikur, Bera Ranajit, Dutta Sriparna, Das Saha Krishna, Das Neeladri
机构信息
Department of Chemistry, Indian Institute of Technology Patna, Patna 801106, Bihar, India.
Cancer & Inflammatory Disorder Division, CSIR-Indian Institute of Chemical Biology, Kolkata 700032, India.
出版信息
ACS Omega. 2020 Feb 21;5(8):4250-4260. doi: 10.1021/acsomega.9b04160. eCollection 2020 Mar 3.
A set of unique triptycene-based and organic Schiff-base-linked polymers (s) are conveniently synthesized in which triptycene motifs are connected with 1,3,5-triformylphloroglucinol units via Schiff-base linkages. s are amorphous, thermally stable with a reasonable surface area (SA up to 649 m/g), and have abundant nanopores (pore size < 100 nm). s are good sorbents for small gas molecules (such as CO, H, and N) and they can selectively capture CO over N. Additionally, s show superior antiproliferative activity against human colorectal cancer cells relative to previously reported covalent organic frameworks (COFs). The mechanism of cell death is also studied elaborately.
通过席夫碱连接方便地合成了一组独特的基于三蝶烯和有机席夫碱连接的聚合物，其中三蝶烯基序通过席夫碱键与间苯三酚三甲醛单元相连。这些聚合物是非晶态的，热稳定性良好，具有合理的表面积（高达649平方米/克），并且有丰富的纳米孔（孔径<100纳米）。它们是小分子气体（如一氧化碳、氢气和氮气）的良好吸附剂，并且相对于之前报道的共价有机框架（COF），它们可以选择性地捕获一氧化碳而不是氮气。此外，相对于之前报道的共价有机框架，这些聚合物对人结肠癌细胞显示出优异的抗增殖活性。还对细胞死亡机制进行了深入研究。
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