Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Drug Metab Rev. 2020 May;52(2):299-318. doi: 10.1080/03602532.2020.1734021. Epub 2020 Mar 9.
Gold Nanostars (GNS) have attracted tremendous attention toward themselves owing to their multi-branched structure and unique properties. These state of the art metallic nanoparticles possess intrinsic features like remarkable optical properties and exceptional physiochemical activities. These star-shaped gold nanoparticles can predominantly be utilized in biosensing, photothermal therapy, imaging, surface-enhanced Raman spectroscopy and target drug delivery applications due to their low toxicity and extraordinary optical features. In the current review, recent approaches in the matter of GNS in case of diagnosis, bioimaging and biomedical applications were summarized and reported. In this regard, first an overview about the structure and general properties of GNS were reported and thence detailed information regarding the diagnostic, bioimaging, photothermal therapy, and drug delivery applications of such novel nanomaterials were presented in detail. Summarized information clearly highlighting the superior capability of GNS as potential multi-functional materials for biomedical applications.
金纳米星（GNS）因其多分支结构和独特的性质而备受关注。这些最先进的金属纳米粒子具有内在的特征，如显著的光学性质和异常的物理化学活性。由于其低毒性和非凡的光学特性，这些星形金纳米粒子主要可以用于生物传感、光热疗法、成像、表面增强拉曼光谱和靶向药物输送应用。在当前的综述中，总结并报道了 GNS 在诊断、生物成像和生物医学应用方面的最新进展。在这方面，首先报道了 GNS 的结构和一般性质概述，然后详细介绍了这种新型纳米材料在诊断、生物成像、光热治疗和药物输送应用方面的详细信息。总结的信息清楚地突出了 GNS 作为潜在的多功能生物医学应用材料的卓越能力。
