Nanotechnology Innovation Center of Kansas State (NICKS), Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, KS, USA.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2015 Nov-Dec;7(6):779-96. doi: 10.1002/wnan.1341. Epub 2015 Mar 24.
In the past few years, there has been an unprecedented development of gold nanomaterials (AuNMs) for potential clinical applications. Owing to their advantageous physical, chemical, and biological properties, AuNMs have attracted great attention in the nanomedicine arena for applications in biological sensing, biomedical imaging, drug delivery, and photothermal therapy. Their tunable size, shape, and surface characteristics coupled with excellent biocompatibility render them ideal candidates for translation from bench-top to bedside. This review summarizes the recent research on the applications of AuNM with a focus on biomedical diagnostics and therapeutics. The bio-interaction of these NM with cells and their in vivo responses are presented. After reviewing these potential applications, future challenges and prospects are discussed and the suitability of how AuNMs are used as effective tools in clinical medicine is assessed.
在过去的几年中，金纳米材料（AuNMs）在潜在的临床应用方面取得了前所未有的发展。由于其具有优越的物理、化学和生物特性，AuNMs 在纳米医学领域引起了广泛关注，可应用于生物传感、生物医学成像、药物输送和光热治疗。其可调的尺寸、形状和表面特性以及出色的生物相容性使它们成为从实验室到临床应用的理想选择。本综述总结了 AuNM 在生物医学诊断和治疗方面的最新研究进展。重点介绍了这些 NM 与细胞的生物相互作用及其在体内的反应。在回顾这些潜在应用之后，讨论了未来的挑战和前景，并评估了 AuNMs 作为临床医学中有效工具的适用性。
