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How Closely Do Clinical Trial Participants Resemble "Real-World" Patients with Groups 2 and 3 Pulmonary Hypertension? A Structured Review.2组和3组肺动脉高压的临床试验参与者与“真实世界”患者的相似程度如何？一项结构化综述。
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Outcomes of pulmonary vasodilator use in Veterans with pulmonary hypertension associated with left heart disease and lung disease.左心疾病和肺部疾病相关肺动脉高压退伍军人使用肺血管扩张剂的疗效
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本文引用的文献

1
Patients with pulmonary arterial hypertension with and without cardiovascular risk factors: Results from the AMBITION trial.有和没有心血管风险因素的肺动脉高压患者：AMBITION 试验结果。
J Heart Lung Transplant. 2019 Dec;38(12):1286-1295. doi: 10.1016/j.healun.2019.09.010. Epub 2019 Sep 17.
2
Riociguat for idiopathic interstitial pneumonia-associated pulmonary hypertension (RISE-IIP): a randomised, placebo-controlled phase 2b study.利奥西呱特治疗特发性间质性肺炎相关性肺动脉高压（RISE-IIP）：一项随机、安慰剂对照的 2b 期研究。
Lancet Respir Med. 2019 Sep;7(9):780-790. doi: 10.1016/S2213-2600(19)30250-4. Epub 2019 Aug 12.
3
Pulmonary hypertension in chronic lung disease and hypoxia.慢性肺部疾病与低氧血症相关性肺动脉高压
Eur Respir J. 2019 Jan 24;53(1). doi: 10.1183/13993003.01914-2018. Print 2019 Jan.
4
Pulmonary hypertension due to left heart disease.左心疾病所致肺动脉高压。
Eur Respir J. 2019 Jan 24;53(1). doi: 10.1183/13993003.01897-2018. Print 2019 Jan.
5
Phosphodiesterase-5 Inhibitor Therapy for Pulmonary Hypertension in the United States. Actual versus Recommended Use.美国的磷酸二酯酶-5 抑制剂治疗肺动脉高压：实际应用与推荐应用。
Ann Am Thorac Soc. 2018 Jun;15(6):693-701. doi: 10.1513/AnnalsATS.201710-762OC.
6
Increasing Incidence and Prevalence of World Health Organization Groups 1 to 4 Pulmonary Hypertension: A Population-Based Cohort Study in Ontario, Canada.世界卫生组织1至4组肺动脉高压的发病率和患病率不断上升：加拿大安大略省的一项基于人群的队列研究。
Circ Cardiovasc Qual Outcomes. 2018 Feb;11(2):e003973. doi: 10.1161/CIRCOUTCOMES.117.003973.
7
Macitentan in pulmonary hypertension due to left ventricular dysfunction.马西替坦治疗左心功能障碍所致肺动脉高压。
Eur Respir J. 2018 Feb 7;51(2). doi: 10.1183/13993003.01886-2017. Print 2018 Feb.
8
Sildenafil for improving outcomes in patients with corrected valvular heart disease and persistent pulmonary hypertension: a multicenter, double-blind, randomized clinical trial.西地那非改善瓣膜病合并持续性肺动脉高压患者结局的多中心、双盲、随机临床试验。
Eur Heart J. 2018 Apr 14;39(15):1255-1264. doi: 10.1093/eurheartj/ehx700.
9
Representation of Patients With Kidney Disease in Trials of Cardiovascular Interventions: An Updated Systematic Review.心血管介入试验中肾病患者的代表性：一项更新的系统评价。
JAMA Intern Med. 2016 Jan;176(1):121-4. doi: 10.1001/jamainternmed.2015.6102.
10
Pulmonary hypertension in idiopathic pulmonary fibrosis with mild-to-moderate restriction.特发性肺纤维化合并轻中度限制的肺动脉高压。
Eur Respir J. 2015 Nov;46(5):1370-7. doi: 10.1183/13993003.01537-2014. Epub 2015 Aug 6.

How Closely Do Clinical Trial Participants Resemble "Real-World" Patients with Groups 2 and 3 Pulmonary Hypertension? A Structured Review.

作者信息

Gillmeyer Kari R, Rinne Seppo T, Walkey Allan J, Qian Shirley X, Wiener Renda Soylemez

机构信息

Edith Nourse Rogers Veterans HospitalBedford, Massachusettsand.

Boston University School of MedicineBoston, Massachusetts.

出版信息

Ann Am Thorac Soc. 2020 Jun;17(6):779-783. doi: 10.1513/AnnalsATS.202001-003RL.

DOI:10.1513/AnnalsATS.202001-003RL
PMID:32150687
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7258417/
Abstract
摘要