Ghadieh Rachelle, Mattar Bou Mosleh Jocelyne, Al Hayek Sibelle, Merhi Samar, El Hayek Fares Jessy
1Department of Nursing and Health Sciences, Notre Dame University- Louaize (NDU), Zouk Mosbeh, Lebanon.
2Department of Endocrinology, Diabetes, Metabolism and Eating Disorders, University Hospital of Saint-Etienne, Saint-Etienne Cedex, France.
BMC Nutr. 2018 Oct 11;4:36. doi: 10.1186/s40795-018-0243-x. eCollection 2018.
The prevalence of low vitamin D status and metabolic syndrome is increasing globally and in Lebanon. The objectives of this study are to assess the prevalence of metabolic syndrome (MetS) and its components (elevated triglycerides, low HDL, abdominal obesity defined by high waist circumference, hypertension, impaired fasting blood glucose) and investigate the association between serum 25-hydroxyvitamin D (25(OH)D) concentrations and MetS and its components among a sample of Lebanese adults.
A cross-sectional study was carried out on Notre Dame University employees. A background questionnaire, a short-form of the International Physical Activity Questionnaire and a food frequency questionnaire were administered. Participants were invited to the nutrition laboratory to gather data on anthropometric (height, waist circumference, weight, body composition and body mass index) and biochemical measurements (serum vitamin D, triglycerides, HDL and fasting blood glucose). Vitamin D status was assessed according to the Institute of Medicine cut-offs (inadequate or adequate: 25(OH)D < or ≥ 50 nmol/L).The definition of the Third Report of the National Cholesterol Education Program was used to identify individuals who had MetS. The data were analyzed using the SPSS version 22. < 0.05 was considered statistically significant.
A total of 344 participants (age range of 20 to 74 years) were included in the study. The prevalence of MetS was 23.5%. Among MetS components, central obesity was the most prevalent condition (50.6%), while the least prevalent was impaired fasting blood glucose (20.3%). The odds of having MetS were found to be 2.5 (95% CI 1.3-4.7) higher among those with inadequate vitamin D status, than among those with adequate vitamin D status while controlling for important confounders (age, marital status, education level, income, medical morbidity, smoking and percent body fat and gender). Among the components of MetS, only hypertriglyceridemia (OR: 2.4, 95%CI: 1.3-4.2) and low HDL (OR: 1.8, 95% CI: 1.0-3.0) were associated with inadequate vitamin D status while controlling for important confounders.
Early identification and control of risk factors for cardiovascular diseases in the primary care level is needed, particularly among adults who have low vitamin D status, are obese, and have low income level.
全球及黎巴嫩维生素D水平低下和代谢综合征的患病率正在上升。本研究的目的是评估代谢综合征（MetS）及其组成部分（甘油三酯升高、高密度脂蛋白降低、高腰围定义的腹型肥胖、高血压、空腹血糖受损）的患病率，并调查黎巴嫩成年人样本中血清25-羟基维生素D（25(OH)D）浓度与代谢综合征及其组成部分之间的关联。
对圣母大学员工进行了一项横断面研究。发放了一份背景问卷、一份国际体力活动问卷简表和一份食物频率问卷。邀请参与者到营养实验室收集人体测量数据（身高、腰围、体重、身体成分和体重指数）和生化测量数据（血清维生素D、甘油三酯、高密度脂蛋白和空腹血糖）。根据医学研究所的临界值评估维生素D状态（不足或充足：25(OH)D＜或≥50 nmol/L）。使用国家胆固醇教育计划第三次报告的定义来确定患有代谢综合征的个体。使用SPSS 22版对数据进行分析。P＜0.05被认为具有统计学意义。
共有344名参与者（年龄范围为20至74岁）纳入研究。代谢综合征的患病率为23.5%。在代谢综合征的组成部分中，中心性肥胖最为普遍（50.6%），而空腹血糖受损最为少见（20.3%）。在控制重要混杂因素（年龄、婚姻状况、教育水平、收入、疾病发病率、吸烟、体脂百分比和性别）后，维生素D状态不足者患代谢综合征的几率比维生素D状态充足者高2.5倍（95%可信区间1.3 - 4.7）。在代谢综合征的组成部分中，在控制重要混杂因素后，只有高甘油三酯血症（比值比：2.4，95%可信区间：1.3 - 4.2）和低高密度脂蛋白（比值比：1.8，95%可信区间：1.0 - 3.0）与维生素D状态不足有关。
需要在初级保健层面尽早识别和控制心血管疾病的危险因素，尤其是在维生素D水平低下、肥胖且收入水平低的成年人中。
