Żakowski Witold
Department of Animal and Human Physiology, Faculty of Biology, University of Gdańsk, Wita Stwosza 59, 80-308 Gdańsk, Poland.
Neuroscience. 2020 May 1;433:1-10. doi: 10.1016/j.neuroscience.2020.02.049. Epub 2020 Mar 7.
The fact that neurobiological research is reliant upon laboratory-reared rodents is well known. The following paper discusses this topic broadly, but also aims to highlight other species used in the study of the nervous system and the evolution of animal species usage from the end of World War II through recent investigations. Attention is drawn to the dramatic reduction in the diversity of species used in neuroscience, with a significant shift toward two species, the mouse (Mus musculus) and rat (Rattus norvegicus). Such a limitation in animal species causes many difficulties in the development of new therapies for various neuropsychiatric diseases. Based on numerous scientific publications, the advantages of using a greater diversity of species in neuroscience and the disadvantages of focusing on mice and rats are presented.
神经生物学研究依赖于实验室饲养的啮齿动物，这一事实众所周知。以下论文广泛讨论了这一主题，但也旨在突出用于神经系统研究的其他物种，以及从第二次世界大战结束到最近的研究中动物物种使用的演变。人们注意到神经科学中使用的物种多样性急剧减少，显著转向了两种物种，即小鼠（小家鼠）和大鼠（褐家鼠）。动物物种的这种限制给各种神经精神疾病新疗法的开发带来了许多困难。基于大量科学出版物，本文阐述了在神经科学中使用更多样化物种的优势以及专注于小鼠和大鼠的弊端。
