Radermecker M, Rommain M, Maldague M P, Bury T, Smets P
Service de Pneumologie, CHU SART Tilman, Université de Liège, Belgique.
Int J Immunopharmacol. 1988;10(8):913-7. doi: 10.1016/0192-0561(88)90036-7.
RU 41740 (Biostim) which is a purified glycoprotein extract from Klebsiella pneumoniae, is an orally active non-specific immunostimulant. In guinea pigs, 8 days after a 7 days oral administration of RU 41740 (10 or 100 mg/kg/day), an increase in the cell population of the pulmonary and peritoneal cavities was observed, especially in that of the macrophages. RU 41740 also enhanced the phagocytic activity of both the alveolar and peritoneal macrophages, when their chemotactic activity was not significantly modified. This increase in the number of pulmonary macrophages and the stimulation of their phagocytic function might explain the protective effect afforded by the oral administration of Biostim against respiratory infections in patients with chronic bronchitis.
RU 41740（生物刺激素）是一种从肺炎克雷伯菌中提取的纯化糖蛋白提取物，是一种口服活性非特异性免疫刺激剂。在豚鼠中，口服RU 41740（10或100毫克/千克/天）7天后，再持续8天，观察到肺和腹腔中的细胞数量增加，尤其是巨噬细胞数量增加。当肺泡和腹腔巨噬细胞的趋化活性没有明显改变时，RU 41740还增强了它们的吞噬活性。肺巨噬细胞数量的增加及其吞噬功能的刺激可能解释了口服生物刺激素对慢性支气管炎患者呼吸道感染的保护作用。
