人群中 H7N9 感染的血清流行率：系统评价和荟萃分析。
Seroprevalence of H7N9 infection among humans: A systematic review and meta-analysis.
机构信息
Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.
Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China.
出版信息
Influenza Other Respir Viruses. 2020 Sep;14(5):587-595. doi: 10.1111/irv.12736. Epub 2020 Mar 10.
In spring 2013, a novel avian-origin influenza A (H7N9) virus emerged in mainland China. The burden of H7N9 infection was estimated based on systematic review and meta-analysis. The systematic search for available literature was conducted using Chinese and English databases. We calculated the pooled seroprevalence of H7N9 infection and its 95% confidence interval by using Freeman-Tukey double arcsine transformation. Out of 16 890 records found using Chinese and English databases, 54 articles were included in the meta-analysis. These included studies of a total of 64 107 individuals. The pooled seroprevalence of H7N9 infection among humans was 0.122% (95% CI: 0.023, 0.275). In high-risk populations, the highest pooled seroprevalence was observed among close contacts (1.075%, 95% CI: 0.000, 4.357). The seroprevalence among general population was (0.077%, 95% CI: 0.011, 0.180). Our study discovered that asymptomatic infection of H7N9 virus did occur, even if the seroprevalence among humans was low.
2013 年春季，中国大陆出现了一种新型的禽流感病毒 A（H7N9）。本研究采用系统评价和荟萃分析的方法来评估 H7N9 感染的负担。系统检索了中、英文数据库中关于 H7N9 感染的相关文献。我们采用 Freeman-Tukey 双反正弦变换法计算了 H7N9 感染的血清流行率及其 95%置信区间。通过中、英文数据库共检索到 16890 条记录，其中 54 篇文献被纳入荟萃分析。这些文献共涉及 64107 例个体。人群中 H7N9 感染的血清流行率为 0.122%（95%CI：0.023，0.275）。在高危人群中，密切接触者的血清流行率最高（1.075%，95%CI：0.000，4.357）。一般人群的血清流行率为（0.077%，95%CI：0.011，0.180）。本研究发现，H7N9 病毒确实存在无症状感染，尽管人群中的血清流行率较低。
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