Vienna Reading Center. Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria.
Vienna Reading Center. Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
Br J Ophthalmol. 2021 Jan;105(1):113-117. doi: 10.1136/bjophthalmol-2019-315311. Epub 2020 Mar 11.
To report on patients with macular neovascularisation type III (MNV3) arising from cilioretinal arteries (CRAs) (cilioretinal macular neovascularisation type III (cMNV3)).
We reviewed baseline examinations of patients with neovascular age-related macular degeneration using multimodal imaging. We determined the type and distribution of MNV lesions in each cMNV3 case, the range of distances from the fovea, existence of exudative maculopathy, intraretinal haemorrhage and other morphological characteristics. 50 consecutive eyes with usual MNV3 without CRA were included as a control group.
102 eyes of 102 patients were identified with MNV3 lesions. Among these, we found 12 eyes (12%) with cMNV3, 84 eyes (82%) with usual MNV3 without CRA and 6 eyes (6%) with usual MNV3 with CRA. Ten cases of cMNV3 had one lesion, and two cases had two lesions. The lesions were distributed equally between the superior and inferior halves of the macula, whereas in the nasal and temporal halves, there were 8 (57%) and 6 (43%) lesions, respectively. All cMNV3 lesions were located between 500 and 1500 µm from the central fovea except one, which was located between 1500 and 3000 µm. None of the lesions had macular neovascularisation type I (MNV1) or macular neovascularisation type II (MNV2) elsewhere in both groups. Exudative maculopathy and intraretinal haemorrhage were found in seven (88%) and five (63%) of the eight pure cMNV3 cases, respectively.
cMNV3 can be solitary or multiple, isolated or accompanied with usual MNV3 lesions, but not with concurrent MNV1 or MNV2. It is frequently associated with extensive exudative maculopathy, intraretinal haemorrhage and subretinal fluid.
报告睫状视网膜动脉（CRA）引起的黄斑新生血管化 III 型（MNV3）患者（睫状视网膜黄斑新生血管化 III 型（cMNV3））。
我们通过多模态成像回顾了新生血管性年龄相关性黄斑变性患者的基线检查。我们确定了每个 cMNV3 病例中 MNV 病变的类型和分布，距黄斑中心凹的距离范围，渗出性黄斑病变、视网膜内出血和其他形态学特征的存在。纳入了 50 只连续的无 CRA 的常发性 MNV3 作为对照组。
共发现 102 只眼中的 102 只眼存在 MNV3 病变。其中，我们发现 12 只眼（12%）有 cMNV3，84 只眼（82%）无 CRA 的常发性 MNV3，6 只眼（6%）有 CRA 的常发性 MNV3。10 例 cMNV3 有一个病变，2 例有两个病变。病变在黄斑的上下两半部分均匀分布，而在鼻侧和颞侧分别有 8（57%）和 6（43%）个病变。所有 cMNV3 病变均位于距中心凹 500 至 1500μm 之间，除了一个病变位于 1500 至 3000μm 之间。两组均无其他部位的 MNV1 或 MNV2 病变。8 例纯 cMNV3 中，7 例（88%）有渗出性黄斑病变，5 例（63%）有视网膜内出血。
cMNV3 可以是单发或多发，孤立或伴有常发性 MNV3 病变，但不伴有同时性 MNV1 或 MNV2。它常伴有广泛的渗出性黄斑病变、视网膜内出血和视网膜下液。
