Shu Bao, Bao Fangjun, Savini Giacomo, Lu Weicong, Tu Ruixue, Chen Haisi, Song Benhao, Wang Qinmei, Huang Jinhai
1School of Ophthalmology and Optometry and Eye Hospital, Wenzhou Medical University, 270 West Xueyuan Road, Wenzhou, 325027 Zhejiang China.
Key Laboratory of Vision Science, Ministry of Health, Wenzhou, Zhejiang People's Republic of China.
Eye Vis (Lond). 2020 Mar 2;7:13. doi: 10.1186/s40662-020-00177-4. eCollection 2020.
To evaluate the effect of orthokeratology on precision of measurements in children using a new swept-source optical coherence tomography (SS-OCT) optical biometer (OA-2000), and agreement between its measurements and those provided by the commonly used IOLMaster based on partial coherence interferometry (PCI).
This study recruited fifty-one eyes of 51 normal children (8-16 years). An operator took measurements with the two biometers. Then, a second operator took measurements with the SS-OCT biometer. After orthokeratology was performed for one month, the same operators repeated the same procedures. Axial length (AL), mean keratometry (Km) at 2.5 mm and 3.0 mm diameters (Km and Km), central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness (LT) and corneal diameter (CD) were analyzed.
With the SS-OCT optical biometer, the test-retest repeatability of AL measurements was < 0.06 mm. For all parameters, the coefficients of variation were < 1.23% and the intraclass correlation coefficients were > 0.95. The 95% limits of agreement of difference between the two devices for CD parameter were up to 1.53 mm. After orthokeratology, the fluctuation ranges of difference for Km3.0 measurement was 1.11 times higher than before orthokeratology, while the absolute values of difference for AL, Km2.5, ACD and CD measurements were comparable.
Before and after orthokeratology, the SS-OCT biometer showed high repeatability and reproducibility for all measurements. Wearing orthokeratology contact lenses affected the agreement between SS-OCT and PCI biometers for Km3.0 measurements. The CD measurement showed poor agreement between the two devices.
使用新型扫频光学相干断层扫描（SS-OCT）光学生物测量仪（OA-2000）评估角膜塑形术对儿童测量精度的影响，以及该仪器与基于部分相干干涉测量法（PCI）的常用IOLMaster测量结果之间的一致性。
本研究招募了51名正常儿童（8至16岁）的51只眼睛。一名操作人员使用这两种生物测量仪进行测量。然后，第二名操作人员使用SS-OCT生物测量仪进行测量。在进行角膜塑形术一个月后，相同的操作人员重复相同的程序。分析眼轴长度（AL）、直径2.5毫米和3.0毫米处的平均角膜曲率（Km）、中央角膜厚度（CCT）、前房深度（ACD）、晶状体厚度（LT）和角膜直径（CD）。
使用SS-OCT光学生物测量仪时，AL测量的重测重复性<0.06毫米。对于所有参数，变异系数<1.23%，组内相关系数>0.95。两种仪器CD参数差异的95%一致性界限高达1.53毫米。角膜塑形术后，Km3.0测量差异的波动范围比角膜塑形术前高1.11倍，而AL、Km2.5、ACD和CD测量差异的绝对值相当。
角膜塑形术前后，SS-OCT生物测量仪对所有测量均显示出高重复性和再现性。佩戴角膜塑形术隐形眼镜影响了SS-OCT和PCI生物测量仪在Km测量上的一致性。两种仪器在CD测量上的一致性较差。
