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银屑病关节炎遗传学的复杂性。

Complexities in Genetics of Psoriatic Arthritis.

机构信息

Department of Medicine, Faculty of Medicine, Memorial University, St. John's, Newfoundland and Labrador, A1B 3X9, Canada.

Krembil Research Institute, University Health Network, Toronto, Ontario, M5S 1A8, Canada.

出版信息

Curr Rheumatol Rep. 2020 Mar 12;22(4):10. doi: 10.1007/s11926-020-0886-x.

DOI:10.1007/s11926-020-0886-x
PMID:32166449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7067725/
Abstract

PURPOSE OF THE REVIEW

To provide a general overview and current challenges regarding the genetics of psoriatic disease. With the use of integrative medicine, multiple candidate loci identified to date in psoriatic disease will be annotated, summarized, and visualized. Recent studies reporting differences in genetic architecture between psoriatic arthritis and cutaneous-only psoriasis will be highlighted.

RECENT FINDINGS

Focusing on functional pathways that connect previously identified genetic variants can increase our understanding of psoriatic diseases. The genetic architecture differs between psoriatic arthritis and cutaneous-only psoriasis with arthritis-specific signals in linkage disequilibrium independent of the published psoriasis signals. Integrative medicine is helpful in understanding cellular mechanisms of psoriatic diseases. Careful selection of the psoriatic disease cohort has translated into mechanistic differences among psoriatic arthritis and cutaneous psoriasis.

摘要

综述目的

提供关于银屑病遗传学的概述和当前挑战。通过综合医学的应用，目前在银屑病中确定的多个候选基因座将被注释、总结和可视化。将重点介绍最近报道的银屑病关节炎和单纯皮肤银屑病之间遗传结构差异的研究。

最近的发现

关注连接先前确定的遗传变异的功能途径可以增加我们对银屑病的理解。银屑病关节炎和单纯皮肤银屑病的遗传结构不同，关节炎特异性信号与已发表的银屑病信号无关，处于连锁不平衡中。综合医学有助于理解银屑病的细胞机制。对银屑病患者队列的精心选择导致了银屑病关节炎和皮肤银屑病之间的机制差异。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe5b/7067725/c94239177f06/11926_2020_886_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe5b/7067725/c94239177f06/11926_2020_886_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe5b/7067725/c94239177f06/11926_2020_886_Fig1_HTML.jpg

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