Department of Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, PR China.
Future Oncol. 2020 Apr;16(10):559-571. doi: 10.2217/fon-2020-0010. Epub 2020 Mar 13.
To explore the prognostic value of the systemic inflammatory marker (SIM) based on neutrophil, lymphocyte and monocyte counts in head and neck squamous cell carcinoma (HNSCC) patients. We retrospectively collected the data of 367 patients with HNSCC who underwent surgery. The Kaplan-Meier survival analysis and Cox regression analysis were conducted on disease-free survival and overall survival. A high SIM (>1.34) was associated with larger tumor size, advanced clinical stage and shorter survival time. The survival analysis showed that only clinical stage and SIM were independent prognostic indicators of disease-free survival and overall survival. The SIM positively correlated with tumor progression and might be a powerful prognostic indicator of poor outcome in patients with HNSCC.
探讨基于中性粒细胞、淋巴细胞和单核细胞计数的全身炎症标志物（SIM）对头颈部鳞状细胞癌（HNSCC）患者预后的预测价值。我们回顾性收集了 367 例接受手术的 HNSCC 患者的数据。对无病生存率和总生存率进行了 Kaplan-Meier 生存分析和 Cox 回归分析。高 SIM（>1.34）与肿瘤体积较大、临床分期较晚和生存时间较短有关。生存分析表明，只有临床分期和 SIM 是无病生存率和总生存率的独立预后指标。SIM 与肿瘤进展呈正相关，可能是 HNSCC 患者预后不良的有力预后指标。
