Division of Infection Control and Prevention, Osaka University Hospital, Japan; Laboratory for Clinical Investigation, Osaka University Hospital, Japan; Department of Biomedical Informatics, Osaka University Graduate School of Medicine, Osaka, Japan.
Division of Infection Control and Prevention, Osaka University Hospital, Japan; Laboratory for Clinical Investigation, Osaka University Hospital, Japan.
J Infect Chemother. 2020 Jul;26(7):681-684. doi: 10.1016/j.jiac.2020.02.011. Epub 2020 Mar 10.
Cytomegalovirus (CMV) are ubiquitously distributed worldwide, causing a wide range of clinical manifestations from congenital infection to a life-threatening disease in immunocompromised individuals. CMV can be transmitted via human-to-human contact through body fluids; however, the risk of CMV infection among healthcare workers (HCWs) has not been fully evaluated.
This study aimed to assess the risk of CMV infection among HCWs through daily medical practices.
Serum samples from HCWs at Osaka University Hospital (Japan) were analysed. Initially, we compared CMV IgG seropositivity among HCWs (medical doctors, nurses, and others) in 2017, which was examined after 1 year to evaluate seroconversion rates among those with seronegative results. Then, we examined CMV seroconversion rates in HCWs who were exposed to blood and body fluids.
We analysed 1153 samples of HCWs (386 medical doctors, 468 nurses, and 299 others), of which CMV seropositivity rates were not significantly different (68.9%, 70.3%, and 70.9%, respectively). Of these, 63.9% (221/346) of CMV seronegative HCWs were followed after 1 year, with CMV seroconversion rates of 3.2% (7/221). Among 72 HCWs who tested negative for CMV IgG when exposed to blood and body fluids, the CMV seroconversion rate was 2.8% (2/72). The CMV seroconversion rates between the two situations were not significantly different.
Our study indicated that CMV infection through daily patient care seems quite rare. Further well-designed studies with a large sample size are warranted to verify our finding.
巨细胞病毒（CMV）在全球范围内广泛分布，可导致从先天性感染到免疫功能低下个体的危及生命疾病等多种临床表现。CMV 可通过人体体液进行人与人之间的传播；然而，医护人员（HCWs）中 CMV 感染的风险尚未得到充分评估。
本研究旨在评估 HCWs 通过日常医疗实践感染 CMV 的风险。
分析了日本大阪大学医院（日本）的 HCWs 的血清样本。最初，我们比较了 2017 年 HCWs（医生、护士和其他人员）中的 CMV IgG 血清阳性率，1 年后对血清阴性结果者的血清转化率进行评估。然后，我们检查了接触血液和体液的 HCWs 中的 CMV 血清转化率。
我们分析了 1153 例 HCWs（386 名医生、468 名护士和 299 名其他人员）的样本，CMV 血清阳性率无显著差异（分别为 68.9%、70.3%和 70.9%）。其中，1 年后对 63.9%（221/346）的 CMV 血清阴性 HCWs 进行了随访，血清转化率为 3.2%（7/221）。在接触血液和体液时 CMV IgG 检测阴性的 72 名 HCWs 中，CMV 血清转化率为 2.8%（2/72）。两种情况下的 CMV 血清转化率无显著差异。
我们的研究表明，通过日常患者护理感染 CMV 似乎相当罕见。需要进一步进行设计良好、样本量大的研究来验证我们的发现。
