Faculty of Medical Sciences, Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Wellcome Sanger Institute, Hinxton, UK.
Immunology. 2020 Jun;160(2):149-156. doi: 10.1111/imm.13192. Epub 2020 Apr 14.
Establishment of a well-functioning immune network in skin is crucial for its barrier function. This begins in utero alongside the structural differentiation and maturation of skin, and continues to expand and diversify across the human lifespan. The microenvironment of the developing human skin supports immune cell differentiation and has an overall anti-inflammatory profile. Immunologically inert and skewed immune populations found in developing human skin promote wound healing, and as such may play a crucial role in the structural changes occurring during skin development.
在皮肤中建立一个功能良好的免疫网络对于其屏障功能至关重要。这始于胚胎期,伴随着皮肤的结构分化和成熟,并在人类的整个生命周期中不断扩展和多样化。发育中人类皮肤的微环境支持免疫细胞的分化,并具有整体抗炎的特征。在发育中的人类皮肤中发现的免疫惰性和倾斜的免疫群体促进伤口愈合,因此可能在皮肤发育过程中发生的结构变化中发挥关键作用。