Department of Obstetrics and Gynecology, Dalhousie University, Halifax, Canada.
Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, Canada.
J Womens Health (Larchmt). 2020 Sep;29(9):1209-1215. doi: 10.1089/jwh.2019.8008. Epub 2020 Mar 13.
Endometriosis is a complex condition that can negatively affect a woman's quality of life, including her sleep. This study aims to assess the multifactorial variables associated with poorer quality of sleep in women with endometriosis. Data from the Endometriosis Pelvic Pain Interdisciplinary Cohort (EPPIC) data registry were analyzed for women who underwent surgery at the BC Women's Center for Pelvic Pain and Endometriosis with histopathological confirmation of endometriosis (June 2015 to June 2017). The primary outcome was quality of sleep preoperatively, from the Chronic Pain Sleep Inventory (0-100 VAS). Bivariate analysis and multivariable linear regression were done to determine any significant associations between preoperative patient variables and overall quality of sleep, based on -value of 0.05. Two hundred and seventy-five women met the study criteria. Poorer overall quality of sleep was independently associated with poorer functional quality of life (EHP-30) (b = -0.18, = 0.0026), more depressive symptoms (PHQ-9) (b = -1.62, < 0.001), and painful bladder syndrome (PBS) (b = -5.82, = 0.035). This indicates that a 1 point increase in the EHP-30 (worsening quality of life), a 1 point increase in the PHQ-9 (worsening depression), and the presence of PBS increased the primary outcome (., toward poorer quality of sleep) by 0.18, 1.62, and 5.82 points. Poorer quality of sleep in women with endometriosis is associated with poorer quality of life, more depressive symptoms, and bladder pain. Research into interventions that improve sleep is warranted as part of the management of some women with endometriosis.
子宫内膜异位症是一种复杂的疾病，会降低女性的生活质量，包括睡眠质量。本研究旨在评估与子宫内膜异位症女性睡眠质量较差相关的多因素变量。对在 BC 妇女盆腔疼痛和子宫内膜异位症中心接受手术且组织病理学证实为子宫内膜异位症的 EPPIC 数据登记处的女性（2015 年 6 月至 2017 年 6 月）的数据进行了分析。主要结果是术前的睡眠质量，来自慢性疼痛睡眠量表（0-100VAS）。进行了双变量分析和多变量线性回归，以确定术前患者变量与总体睡眠质量之间是否存在任何显著关联，以 0.05 为检验水准。275 名女性符合研究标准。总体睡眠质量较差与功能生活质量较差（EHP-30）（b=-0.18， =0.0026）、抑郁症状更严重（PHQ-9）（b=-1.62， <0.001）和膀胱疼痛综合征（PBS）（b=-5.82， =0.035）独立相关。这表明，EHP-30 增加 1 分（生活质量恶化）、PHQ-9 增加 1 分（抑郁恶化）和存在 PBS 会使主要结局（朝着睡眠质量恶化的方向）增加 0.18、1.62 和 5.82 分。子宫内膜异位症女性睡眠质量较差与生活质量较差、抑郁症状更严重和膀胱疼痛有关。需要研究改善睡眠的干预措施，作为一些子宫内膜异位症女性管理的一部分。
