Baek Seungho, Park Heekyung, Park Youngah, Kang Hyun, Lee Donghyun
Department of Biomedical Engineering, School of Integrative Engineering, Chung-Ang University, 221 Heukseok-Dong, Dongjak-Gu, Seoul 156-756, Korea.
Department of Anesthesiology and Pain Medicine, Chung-Ang University College of Medicine and Graduate School of Medicine, Seoul 06973, Korea.
Polymers (Basel). 2020 Mar 8;12(3):618. doi: 10.3390/polym12030618.
Surgery, particularly open surgery, is known to cause tissue/organ adhesion during healing. These adhesions occur through contact between the surgical treatment site and other organ, bone, or abdominal sites. Fibrous bands can form in unnecessary contact areas and cause various complications. Consequently, film- and gel-type anti-adhesion agents have been developed. The development of sustained drug delivery systems is very important for disease treatment and prevention. In this study, the drug release behavior was controlled by crosslinking lidocaine-loaded alginate/carboxymethyl cellulose (CMC)/polyethylene oxide (PEO) nanofiber films prepared by electrospinning. Lidocaine is mainly used as an anesthetic and is known to have anti-adhesion effects. Our results show that drug release is regulated by the crosslinking degree of the lidocaine-loaded alginate/CMC/PEO film. The drug release behavior was confirmed by HPLC, and, as a result, an excellent anti-adhesion barrier was developed that can be applied to treat patients in the medical field.
众所周知，手术尤其是开放手术在愈合过程中会导致组织/器官粘连。这些粘连是通过手术治疗部位与其他器官、骨骼或腹部部位之间的接触而发生的。在不必要的接触区域会形成纤维带，并引发各种并发症。因此，已经开发出了薄膜型和凝胶型抗粘连剂。持续给药系统的开发对于疾病的治疗和预防非常重要。在本研究中，通过静电纺丝制备的负载利多卡因的海藻酸盐/羧甲基纤维素（CMC）/聚环氧乙烷（PEO）纳米纤维膜的交联来控制药物释放行为。利多卡因主要用作麻醉剂，并且已知具有抗粘连作用。我们的结果表明，负载利多卡因的海藻酸盐/CMC/PEO膜的交联度可调节药物释放。通过高效液相色谱法（HPLC）确认了药物释放行为，结果开发出了一种出色的抗粘连屏障，可应用于医学领域的患者治疗。
