Department of Radiology, Affiliated Nantong Hospital 3 of Nantong University, #99 Youth Middle Road, Chongchuan District, Nantong, 226000, Jiangsu, China.
Nantong University, #19 Qixiu Road, Chongchuan District, Nantong, 226000, Jiangsu, China.
Abdom Radiol (NY). 2020 Oct;45(10):3129-3135. doi: 10.1007/s00261-020-02478-7.
This study aimed to evaluate the feasibility of using the hepatocyte enhancement fraction (HEF) based on gadoxetic acid-enhanced magnetic resonance imaging (MRI) for assessing the liver function in patients with chronic hepatitis B.
Sixty patients with Child-Pugh grade A (CP-A), 18 with Child-Pugh grade B (CP-B), 2 with Child-Pugh grade C (CP-C), and 20 with normal liver function (NLF) were enrolled. Gadolinium ethoxybenzyldiethy-lenetriaminepentaacetic acid (Gd-EOB-DTPA)-enhanced MRI was conducted. T1 mapping imaging was performed before and 20 min after Gd-EOB-DTPA administration. The pre- and post-contrast T1 values of the liver (T1pre and T1post), increase in the T1 relaxation rate (ΔR1), rate of decrease in the T1 relaxation time (ΔT1), HEF, and uptake coefficient (K) parameters in the NLF, CP-A, and CP-B + CP-C groups were compared using one-way analysis of variance. The effectiveness of each parameter in differentiating the NLF + CP-A group from the CP-B + CP-C group was evaluated using the receiver operating characteristic (ROC) curve.
The HEF, K, ΔT1, and ΔR1 values decreased, while the T1post and T1pre values increased, with the increase in liver function damage. Significant differences in T1post, ΔT1, ΔR1, and HEF were found between different groups, except for the CP-A and NLF groups. However, no significant difference was observed in the T1pre among the three groups. HEF exhibited the largest area under the ROC curve.
The HEF is an effective method for evaluating liver function in patients with hepatitis B.
本研究旨在评估基于钆塞酸增强磁共振成像（MRI）的肝细胞增强分数（HEF）评估慢性乙型肝炎患者肝功能的可行性。
纳入 60 例 Child-Pugh 分级为 A（CP-A）、18 例 Child-Pugh 分级为 B（CP-B）、2 例 Child-Pugh 分级为 C（CP-C）和 20 例肝功能正常（NLF）患者。进行钆乙氧苯甲基二乙三胺五乙酸（Gd-EOB-DTPA）增强 MRI，在 Gd-EOB-DTPA 给药前和给药后 20 分钟进行 T1 映射成像。比较 NLF、CP-A 和 CP-B+CP-C 组的肝 T1 值（T1pre 和 T1post）、T1 弛豫率的增加（ΔR1）、T1 弛豫时间的减少率（ΔT1）、HEF 和摄取系数（K）参数的变化。使用单因素方差分析比较 NLF+CP-A 组和 CP-B+CP-C 组之间每个参数的有效性。使用受试者工作特征（ROC）曲线评估每个参数区分 NLF+CP-A 组和 CP-B+CP-C 组的效果。
随着肝功能损害的增加，HEF、K、ΔT1 和 ΔR1 值降低，而 T1post 和 T1pre 值升高。除 CP-A 和 NLF 组外，不同组之间的 T1post、ΔT1、ΔR1 和 HEF 值存在显著差异。然而，三组之间的 T1pre 值无显著差异。HEF 显示出最大的 ROC 曲线下面积。
HEF 是评估乙型肝炎患者肝功能的有效方法。
