Obmann Verena Carola, Catucci Damiano, Berzigotti Annalisa, Gräni Christoph, Ebner Lukas, Heverhagen Johannes Thomas, Christe Andreas, Huber Adrian Thomas
Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 10, 3010, Bern, Switzerland.
Hepatology, Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Sci Rep. 2022 Mar 18;12(1):4716. doi: 10.1038/s41598-022-08659-2.
Magnetic resonance T1 mapping before and after Gd-EOB-DTPA administration allows quantification of the T1 reduction rate as a non-invasive surrogate marker of liver function. A major limitation of T1 relaxation time measurement is its dependency on MRI field strengths. Since T1 reduction rate is calculated as the relative shortening of T1 relaxation time before and after contrast administration, we hypothesized that the T1 reduction rate is comparable between 1.5 and 3 T. We thus compared liver T1 relaxation times between 1.5 and 3 T in a total of 243 consecutive patients (124, 1.5 T and 119, 3 T) between 09/2018 and 07/2019. T1 reduction rates were compared between patients with no cirrhosis and patients with cirrhosis Child-Pugh A-C. There was no significant difference of T1 reduction rate between 1.5 and 3 T in any patient group (p-value 0.126-0.861). On both 1.5 T and 3 T, T1 reduction rate allowed to differentiate between patients with no cirrhosis and patients with liver cirrhosis Child A-C (p < 0.001). T1 reduction rate showed a good performance to predict liver cirrhosis Child A (AUC = 0.83, p < 0.001), Child B (AUC = 0.83, p < 0.001) and Child C (AUC = 0.92, p < 0.001). In conclusion, T1 reduction rate allows to determine liver function on Gd-EOB-DTPA MRI with comparable values on 1.5 T and 3 T.
钆塞酸二钠（Gd-EOB-DTPA）给药前后的磁共振T1映射能够将T1降低率量化为肝功能的一种非侵入性替代标志物。T1弛豫时间测量的一个主要局限在于其对磁共振成像（MRI）场强的依赖性。由于T1降低率是通过对比剂给药前后T1弛豫时间的相对缩短来计算的，我们推测1.5T和3T时的T1降低率具有可比性。因此，我们在2018年9月至2019年7月期间，对连续的243例患者（124例为1.5T，119例为3T）的肝脏T1弛豫时间在1.5T和3T之间进行了比较。对无肝硬化患者和肝硬化Child-Pugh A-C级患者的T1降低率进行了比较。在任何患者组中，1.5T和3T之间的T1降低率均无显著差异（p值为0.126 - 0.861）。在1.5T和3T上，T1降低率均能够区分无肝硬化患者和肝硬化Child A-C级患者（p＜0.001）。T1降低率在预测肝硬化Child A级（曲线下面积[AUC]=0.83，p＜0.001）、Child B级（AUC=0.83，p＜0.001）和Child C级（AUC=0.92，p＜0.001）方面表现良好。总之，T1降低率能够在钆塞酸二钠MRI上测定肝功能，且在1.5T和3T时具有可比的值。
