Department of Psychiatry and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.
Department of Neurology, Nizam's Institute of Medical Sciences, Hyderabad, India.
Arch Clin Neuropsychol. 2020 Jul 24;35(5):528-538. doi: 10.1093/arclin/acaa013.
With the rising burden of dementia globally, there is a need to harmonize dementia research across diverse populations. The Addenbrooke's Cognitive Examination-III (ACE-III) is a well-established cognitive screening tool to diagnose dementia. But there have been few efforts to standardize the use of ACE-III across cohorts speaking different languages. The present study aimed to standardize and validate ACE-III across seven Indian languages and to assess the diagnostic accuracy of the test to detect dementia and mild cognitive impairment (MCI) in the context of language heterogeneity.
The original ACE-III was adapted to Indian languages: Hindi, Telugu, Kannada, Malayalam, Urdu, Tamil, and Indian English by a multidisciplinary expert group. The ACE-III was standardized for use across all seven languages. In total, 757 controls, 242 dementia, and 204 MCI patients were recruited across five cities in India for the validation study. Psychometric properties of adapted versions were examined and their sensitivity and specificity were established.
The sensitivity and specificity of ACE-III in identifying dementia ranged from 0.90 to 1, sensitivity for MCI ranged from 0.86 to 1, and specificity from 0.83 to 0.93. Education but not language was found to have an independent effect on ACE-III scores. Optimum cut-off scores were established separately for low education (≤10 years of education) and high education (>10 years of education) groups.
The adapted versions of ACE-III have been standardized and validated for use across seven Indian languages, with high diagnostic accuracy in identifying dementia and MCI in a linguistically diverse context.
随着全球痴呆症负担的增加，需要协调不同人群的痴呆症研究。Addenbrooke's 认知测验-III（ACE-III）是一种用于诊断痴呆症的成熟认知筛查工具。但是，很少有努力使不同语言的队列标准化使用 ACE-III。本研究旨在标准化和验证 ACE-III 在七种印度语言中的应用，并评估该测试在语言异质性背景下检测痴呆症和轻度认知障碍（MCI）的诊断准确性。
由多学科专家组将原始 ACE-III 改编为印度语言：印地语、泰卢固语、卡纳达语、马拉雅拉姆语、乌尔都语、泰米尔语和印度英语。ACE-III 已标准化可用于所有七种语言。在印度的五个城市共招募了 757 名对照者、242 名痴呆症患者和 204 名 MCI 患者进行验证研究。检验了改编版本的心理测量特性，并确定了其敏感性和特异性。
ACE-III 用于识别痴呆症的敏感性和特异性范围为 0.90 到 1，用于识别 MCI 的敏感性范围为 0.86 到 1，特异性范围为 0.83 到 0.93。教育而不是语言被发现对 ACE-III 分数有独立影响。为低教育（≤10 年教育）和高教育（>10 年教育）组分别建立了最佳截断分数。
已经为 ACE-III 的七种印度语言改编版本进行了标准化和验证，在语言多样化的背景下，具有识别痴呆症和 MCI 的高诊断准确性。
