Belisle Richard S, Via Christopher W, Schock Tracey B, Villareal Tracy A, Zimba Paul V, Beauchesne Kevin R, Moeller Peter D R, Bertin Matthew J
Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, 7 Greenhouse Road, Kingston, RI 02881, United States.
National Institutes of Standards and Technology, Hollings Marine Laboratory, 331 Fort Johnson Road, Charleston, SC 29412, United States.
Tetrahedron Lett. 2017 Oct 25;58(43):4066-4068. doi: 10.1016/j.tetlet.2017.09.027. Epub 2017 Sep 17.
Mass spectrometry-guided isolation of the lipophilic extract of bloom material led to the isolation and structure characterization of a new thiazole-containing di-chlorinated polyketide (). The structure of was deduced using 1D and 2D NMR analysis, high-resolution mass spectrometry analysis and complementary spectroscopic procedures. Trichothiazole A possesses interesting structural features, such as a terminal alkyne, two vinyl chlorides and a 2,4-disubstituted thiazole. Trichothiazole A showed moderate cytotoxicity to Neuro-2A cells (EC: 13.3 ± 1.1 μM).
对水华物质的亲脂性提取物进行质谱引导的分离，得到了一种新的含噻唑二氯代聚酮化合物（）的分离和结构表征。通过一维和二维核磁共振分析、高分辨率质谱分析及补充光谱方法推导了的结构。曲古噻唑A具有有趣的结构特征，如末端炔烃、两个氯乙烯基和一个2,4-二取代噻唑。曲古噻唑A对Neuro-2A细胞显示出中等细胞毒性（半数有效浓度：13.3±1.1μM）。
