Chen Cheng, You Fei, Wu FengHua, Luo YuShen, Zheng GuoHua, Xu HanLin, Liu Yi
Department of Medicinal Chemistry, School of Pharmacy, Hubei University of Chinese Medicine, Wuhan 430065, China.
Evid Based Complement Alternat Med. 2020 Feb 29;2020:2390125. doi: 10.1155/2020/2390125. eCollection 2020.
Natural plants are considered as a huge treasure for anticancer. , a plant of Zingiberaceae, is used widely as a food and traditional medicine in East Asia. In previous studies, has antitumor effect on liver cancer cells, but the mechanism is not clear. Here, we demonstrated that ethanol extract from (At-EE) could inhibit ovarian cancer and decrease angiogenesis . At-EE did not influence vascular endothelial cells directly, but decreased IL-6 and VEGF secreted by ovarian cancer cells to inhibit angiogenesis through inhibition of p-STAT3 and NF-kB activation. In addition, we demonstrated that p-STAT3 and NF-kB could adjust each other and IL-6 and VEGF also mediate p-STAT3 and NF-kB too, which created a loop. In addition, At-EE interrupted p-STAT3/NF-kB/IL-6 and VEGF loop through induced ER stress. These results reveal that p-STAT3/NF-kB/IL-6 and VEGF is a cascade amplification loop in ovarian cancer for angiogenesis, and induced ER stress can interrupt it. Taken together, this work explored the anticancer activities of , which could be a potential therapeutic candidate in the treatment of ovarian cancer.
天然植物被认为是抗癌的巨大宝库。姜科植物[此处原文缺失植物名称]在东亚被广泛用作食物和传统药物。在先前的研究中，[此处原文缺失植物名称]对肝癌细胞有抗肿瘤作用，但机制尚不清楚。在此，我们证明了[此处原文缺失植物名称]的乙醇提取物（At-EE）可以抑制卵巢癌并减少血管生成。At-EE不会直接影响血管内皮细胞，而是通过抑制p-STAT3和NF-κB的激活来降低卵巢癌细胞分泌的IL-6和VEGF，从而抑制血管生成。此外，我们证明了p-STAT3和NF-κB可以相互调节，IL-6和VEGF也介导p-STAT3和NF-κB，从而形成一个循环。此外，At-EE通过诱导内质网应激中断p-STAT3/NF-κB/IL-6和VEGF循环。这些结果表明，p-STAT3/NF-κB/IL-6和VEGF是卵巢癌血管生成中的一个级联放大循环，诱导内质网应激可以中断它。综上所述，这项工作探索了[此处原文缺失植物名称]的抗癌活性，它可能是治疗卵巢癌的潜在候选药物。
