Research Group on Toxic Substances in Livestock and Aquatic Animals, Khon Kaen University, Khon Kaen 40002, Thailand.
Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
Int J Environ Res Public Health. 2020 Mar 17;17(6):1980. doi: 10.3390/ijerph17061980.
This study aimed to investigate the concentrations of Cr, Cd and Pb in the water, sediment and experimental hybrid catfish muscles, and to compare the genetic differentiation and the levels of oxidative stress biomarkers (malondialdehyde and protein carbonyl) between the catfish from the contaminated reservoir near a municipal landfill and the reference area after chronic exposure. The concentrations of all metals in the water and the concentration of Cd in the sediment exceeded Thailand's surface water quality and soil quality standards, respectively, whereas the concentrations of these metals in fish muscles did not exceed Thailand's food quality standards. Dendrogram results in terms of genetic similarity values of the catfish from the reference and the landfill areas were 0.90 to 0.96 and 0.79 to 0.86, respectively, implying that the genetic differentiation of the fish from the landfill was greater than of those from the reference area. The fish in the landfill reservoir had slightly increased protein carbonyl levels. The results indicate that chronic heavy metal exposure can cause genotoxicity of the hybrid catfish and induce protein carbonyl as an oxidative stress biomarker in the reservoir near a municipal landfill.
本研究旨在调查水中、沉积物中和实验杂交鲶鱼肌肉中 Cr、Cd 和 Pb 的浓度，并比较在慢性暴露后，来自市政垃圾填埋场附近污染水库和对照区的鲶鱼之间的遗传分化和氧化应激生物标志物（丙二醛和蛋白质羰基）水平。水和沉积物中所有金属的浓度以及 Cd 的浓度分别超过了泰国地表水质量和土壤质量标准，而鱼类肌肉中这些金属的浓度未超过泰国食品质量标准。参照区和填埋区鲶鱼的遗传相似性值的聚类分析结果分别为 0.90 至 0.96 和 0.79 至 0.86，表明来自填埋区的鱼类遗传分化大于来自参照区的鱼类。来自填埋场水库的鱼的蛋白质羰基水平略有升高。结果表明，慢性重金属暴露会导致杂交鲶鱼的遗传毒性，并在市政垃圾填埋场附近的水库中诱导蛋白质羰基作为氧化应激生物标志物。
