Neoptolemos J P, Clayton H, Heagerty A M, Nicholson M J, Johnson B, Mason J, Manson K, James R F, Bell P R
Department of Surgery, Leicester Royal Infirmary, UK.
Br J Cancer. 1988 Nov;58(5):575-9. doi: 10.1038/bjc.1988.262.
Fatty acids were determined in erthrocytes in 49 patients with colorectal cancer and compared with age and sex-matched controls. Marginally increased levels of stearic acid (P = 0.057) and oleic acid (P = 0.064) and decreased arachidonic acid (P = 0.043) occurred in cancer patients. There was no difference in the stearic to oleic acid ratio between the two groups. Dietary intake, assessed by dietary recall and adipose tissue analysis was also not different. In control subjects the polyunsaturated:saturated (P:S) fatty acid ratio correlated between diet and adipose tissue (P less than 0.01, at least). In contrast cancer patients showed different correlations; in particular dietary and erythrocyte P:S fatty acid ratios correlated (P less than 0.01). These findings may indicate disturbed fat metabolism in cancer patients. The erythrocyte stearic to oleic acid ratio is of no diagnostic value.
对49例结直肠癌患者的红细胞脂肪酸进行了测定，并与年龄和性别匹配的对照组进行了比较。癌症患者的硬脂酸水平（P = 0.057）和油酸水平（P = 0.064）略有升高，花生四烯酸水平降低（P = 0.043）。两组之间的硬脂酸与油酸比值没有差异。通过饮食回忆和脂肪组织分析评估的饮食摄入量也没有差异。在对照组中，多不饱和脂肪酸与饱和脂肪酸（P:S）的比值在饮食和脂肪组织之间存在相关性（P至少小于0.01）。相比之下，癌症患者表现出不同的相关性；特别是饮食中的P:S脂肪酸比值与红细胞中的P:S脂肪酸比值相关（P小于0.01）。这些发现可能表明癌症患者存在脂肪代谢紊乱。红细胞硬脂酸与油酸的比值没有诊断价值。
