Ogura Tokuhiro, Takada Hideho, Okuno Masashi, Kitade Hiroaki, Matsuura Takashi, Kwon Masanori, Arita Seizaburo, Hamazaki Kei, Itomura Miho, Hamazaki Tomohito
Division of Surgery, Takii Hospital of Kansai Medical University, Moriguchi, Osaka, Japan.
Lipids. 2010 Feb;45(2):137-44. doi: 10.1007/s11745-010-3386-3. Epub 2010 Jan 22.
The composition of fatty acids in abdominal subcutaneous adipose tissue and the correlation of fatty acid values of plasma and erythrocytes had not been reported in Japan. The aim of the present study was to investigate the fatty acid composition and correlation of plasma and erythrocyte phospholipids (PL) and adipose triacylglycerols (TG) in 75 adult patients admitted for non-malignant diseases. We also examined the relationship of n-3 and n-6 polyunsaturated fatty acid (PUFA) with patients' characteristics. The total n-3 PUFA were 11.2, 11.8 and 1.9%, and the ratios of n-6/n-3 were 2.41, 1.87 and 8.20 in plasma and erythrocyte PL and adipose TG, respectively. There were the highest correlations for total n-3 PUFA and the n-6/n-3 ratio between plasma and erythrocyte PL and adipose TG. There was a positive correlation between n-3 PUFAs and age, but a negative correlation was found between n-6 PUFAs and age. There was no significant difference in the values of PUFAs in plasma and erythrocyte PL and adipose TG between men and women. The patients with cholesterol cholecystolithiasis showed a significantly lower proportion of eicosapentaenoic acid in plasma and erythrocyte PL than those of the other patients. Our findings suggest that PUFA in plasma and erythrocyte PL may be good biomarkers and more acceptable for studying participants than adipose TG.
在日本，尚未有关于腹部皮下脂肪组织中脂肪酸组成以及血浆和红细胞脂肪酸值相关性的报道。本研究的目的是调查75例因非恶性疾病入院的成年患者血浆和红细胞磷脂（PL）以及脂肪组织三酰甘油（TG）的脂肪酸组成及其相关性。我们还研究了n-3和n-6多不饱和脂肪酸（PUFA）与患者特征之间的关系。血浆、红细胞PL和脂肪组织TG中总n-3 PUFA分别为11.2%、11.8%和1.9%，n-6/n-3比值分别为2.41、1.87和8.20。血浆与红细胞PL以及脂肪组织TG之间，总n-3 PUFA和n-6/n-3比值的相关性最高。n-3多不饱和脂肪酸与年龄呈正相关，而n-6多不饱和脂肪酸与年龄呈负相关。男性和女性的血浆、红细胞PL以及脂肪组织TG中PUFA值无显著差异。胆固醇性胆囊炎患者血浆和红细胞PL中二十碳五烯酸的比例显著低于其他患者。我们的研究结果表明，血浆和红细胞PL中的PUFA可能是良好的生物标志物，并且对于研究参与者来说比脂肪组织TG更容易接受。
