Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, No. 100 Science Road, Zhengzhou, 450001, Henan, People's Republic of China.
Department of Social Medicine and Healthcare Management, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, People's Republic of China.
Eur J Nutr. 2020 Dec;59(8):3815-3825. doi: 10.1007/s00394-020-02212-5. Epub 2020 Mar 19.
There is a paucity of data on the association between away-from home meals (AFHs) and type 2 diabetes mellitus (T2DM). The aim of this cross-sectional study was to explore the dose-response relationship between AFHs and T2DM in a Chinese population.
A total of 29,910 participants were enrolled from the Henan Rural Cohort Study. Information on the weekly frequency of AFHs was collected by face-to-face questionnaires. Logistic regression and restricted cubic splines were used to estimate the relationship between the frequencies of AFHs and T2DM. Mediation analysis was performed to examine the contribution of body mass index (BMI) to the frequency of AFH-related T2DM.
Compared with those who reported 0 AFHs per week, those who consumed ≥ 11 AFHs/week were associated with a 39% increase in the prevalence of T2DM. A nonlinear dose-response relationship between the frequency of AFHs and T2DM was found. Compared with the 0 AFHs/week group, in males, the multivariate odds ratios (OR) and 95% confidence interval (95% CI) of the groups with 11 or more AFHs/week for T2DM were 1.36 (1.01-1.84). However, no such association was found in females. BMI partly mediated the effects of the frequency of AFHs on T2DM, and the proportion explained was 23.4%.
A relationship between the frequency of AFHs and T2DM was observed in the rural Chinese population. An excessive frequency of AFHs was likely to increase the prevalence of T2DM. Meanwhile, BMI partially mediates the effects of the frequency of AFHs on T2DM.
The Henan Rural Cohort Study, ChiCTR-OOC-15006699, Registered 6 July 2015, https://www.chictr.org.cn/showproj.aspx?proj=11375 .
有关外出就餐（AFHs）与 2 型糖尿病（T2DM）之间关联的数据很少。本横断面研究的目的是探索中国人群中 AFHs 与 T2DM 之间的剂量-反应关系。
共纳入 29910 名来自河南农村队列研究的参与者。通过面对面问卷收集每周 AFHs 频率的信息。使用逻辑回归和限制立方样条来估计 AFHs 频率与 T2DM 之间的关系。进行中介分析以检验 BMI（体重指数）对 AFH 相关 T2DM 频率的贡献。
与每周报告 0 次 AFHs 的人相比，每周至少食用 11 次 AFHs 的人患 T2DM 的患病率增加了 39%。AFHs 频率与 T2DM 之间存在非线性剂量-反应关系。与每周 0 次 AFHs 组相比，男性每周 11 次或更多次 AFHs 组患 T2DM 的多变量比值比（OR）和 95%置信区间（95%CI）为 1.36（1.01-1.84）。然而，在女性中未发现这种关联。BMI 部分介导了 AFHs 频率对 T2DM 的影响，解释比例为 23.4%。
在农村中国人群中观察到 AFHs 频率与 T2DM 之间存在关系。AFHs 频率过高可能会增加 T2DM 的患病率。同时，BMI 部分介导了 AFHs 频率对 T2DM 的影响。
河南农村队列研究，ChiCTR-OOC-15006699，注册于 2015 年 7 月 6 日，https://www.chictr.org.cn/showproj.aspx?proj=11375。
