COVID-19 在不同物种间关系的分子基础：一种大健康视角。
Molecular basis of COVID-19 relationships in different species: a one health perspective.
机构信息
Department of Health Science, University "Magna Græcia" of Catanzaro, Viale Europa, 88100 Catanzaro, Italy.
Department of Veterinary Sciences, University of Milano, Via Celoria n10, 20133 Milano, Italy.
出版信息
Microbes Infect. 2020 May-Jun;22(4-5):218-220. doi: 10.1016/j.micinf.2020.03.002. Epub 2020 Mar 17.
Abstract
Outside the Hubei province, China, the mild form of infection and the progressive recover of the COVID-19 patients suggest the intervention of "unconventional" biological mechanisms worthy of attention. Based on the high-homology between the Spike protein epitopes of taxonomically-related coronaviruses, we hypothesized that past contact with infected dogs shield humans against the circulating SARS-CoV-2. Elseways, the recurrent virus exposure over a short time-lapse might result in the Antibody Dependent Enhancement, triggering the violent immune reaction responsible for the severe clinical outcomes observed in the Hubei province. Nevertheless, further experimental studies are desired for a confidential evaluation of the postulated hypotheses.
摘要
在中国湖北省外，COVID-19 轻症患者的逐渐康复表明存在值得关注的“非常规”生物学机制。基于分类相关冠状病毒刺突蛋白表位的高度同源性，我们假设过去与感染的犬类接触可使人类免受循环 SARS-CoV-2 的侵害。否则，短时间内反复的病毒暴露可能导致抗体依赖性增强，引发剧烈的免疫反应，这可能是导致湖北省严重临床结果的原因。然而，还需要进一步的实验研究来对假设进行保密评估。
相似文献
1
Molecular basis of COVID-19 relationships in different species: a one health perspective.COVID-19 在不同物种间关系的分子基础：一种大健康视角。
Microbes Infect. 2020 May-Jun;22(4-5):218-220. doi: 10.1016/j.micinf.2020.03.002. Epub 2020 Mar 17.
2
Epitopes for a 2019-nCoV vaccine.2019新型冠状病毒疫苗的表位
Cell Mol Immunol. 2020 May;17(5):539-540. doi: 10.1038/s41423-020-0377-z. Epub 2020 Feb 24.
3
The biological characteristics of SARS-CoV-2 spike protein Pro330-Leu650.SARS-CoV-2 刺突蛋白 Pro330-Leu650 的生物学特性。
Vaccine. 2020 Jul 6;38(32):5071-5075. doi: 10.1016/j.vaccine.2020.04.070. Epub 2020 Apr 30.
4
What about the original antigenic sin of the humans versus SARS-CoV-2?人类对抗新冠病毒时的原始抗原罪是怎么回事？
Med Hypotheses. 2020 Sep;142:109824. doi: 10.1016/j.mehy.2020.109824. Epub 2020 May 7.
5
On the molecular determinants of the SARS-CoV-2 attack.关于严重急性呼吸综合征冠状病毒2（SARS-CoV-2）侵袭的分子决定因素
Clin Immunol. 2020 Jun;215:108426. doi: 10.1016/j.clim.2020.108426. Epub 2020 Apr 18.
6
Targeting SARS-CoV2 Spike Protein Receptor Binding Domain by Therapeutic Antibodies.靶向 SARS-CoV-2 刺突蛋白受体结合域的治疗性抗体。
Biomed Pharmacother. 2020 Oct;130:110559. doi: 10.1016/j.biopha.2020.110559. Epub 2020 Aug 1.
7
Energetics and IC50 based epitope screening in SARS CoV-2 (COVID 19) spike protein by immunoinformatic analysis implicating for a suitable vaccine development.基于能量学和半数抑制浓度的 SARS-CoV-2（COVID-19）刺突蛋白表位筛选的免疫信息学分析，为合适的疫苗开发提供了依据。
J Transl Med. 2020 Jul 10;18(1):281. doi: 10.1186/s12967-020-02435-4.
8
Why do children seem to be more protected against COVID-19? A hypothesis.儿童似乎对 COVID-19 的保护更强？一种假设。
Med Hypotheses. 2020 Oct;143:110151. doi: 10.1016/j.mehy.2020.110151. Epub 2020 Jul 31.
9
The 2020 Pandemic: Current SARS-CoV-2 Vaccine Development.2020 年大流行：当前 SARS-CoV-2 疫苗的开发。
Front Immunol. 2020 Aug 19;11:1880. doi: 10.3389/fimmu.2020.01880. eCollection 2020.
10
Implications of antibody-dependent enhancement of infection for SARS-CoV-2 countermeasures.抗体依赖的感染增强对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）应对措施的影响。
Nat Biotechnol. 2020 Jul;38(7):789-791. doi: 10.1038/s41587-020-0577-1.
引用本文的文献
1
In Vitro Antiviral Activity of the Fungal Metabolite 6-Pentyl-α-Pyrone Against Bovine Coronavirus: A Translational Study to SARS-CoV-2.真菌代谢产物6-戊基-α-吡喃酮对牛冠状病毒的体外抗病毒活性：针对严重急性呼吸综合征冠状病毒2的转化研究
Vet Sci. 2025 Jul 2;12(7):634. doi: 10.3390/vetsci12070634.
2
Antibody-dependent enhancement of coronaviruses.冠状病毒的抗体依赖性增强作用。
Int J Biol Sci. 2025 Feb 3;21(4):1686-1704. doi: 10.7150/ijbs.96112. eCollection 2025.
3
Antigen Delivery Platforms for Next-Generation Coronavirus Vaccines.下一代冠状病毒疫苗的抗原递送平台
Vaccines (Basel). 2024 Dec 31;13(1):30. doi: 10.3390/vaccines13010030.
4
Cross-Reactive Immune Response of Bovine Coronavirus Spike Glycoprotein to SARS-CoV-2 Variants of Concern.牛冠状病毒刺突糖蛋白对关注的 SARS-CoV-2 变体的交叉反应免疫应答。
Int J Mol Sci. 2024 Oct 26;25(21):11509. doi: 10.3390/ijms252111509.
5
Bison, Elk, and Other Captive Wildlife Species Humoral Immune Responses against SARS-CoV-2.野牛、麋鹿及其他圈养野生动物物种对严重急性呼吸综合征冠状病毒2的体液免疫反应
Animals (Basel). 2024 Sep 30;14(19):2829. doi: 10.3390/ani14192829.
6
The bibliometric landscape of infectious disease research in Panama (1990-2019).巴拿马传染病研究的文献计量图景（1990 - 2019年）
Dialogues Health. 2023 Feb 24;2:100117. doi: 10.1016/j.dialog.2023.100117. eCollection 2023 Dec.
7
Intracellular Degradation of SARS-CoV-2 N-Protein Caused by Modular Nanotransporters Containing Anti-N-Protein Monobody and a Sequence That Recruits the Keap1 E3 Ligase.由包含抗N蛋白单克隆抗体和招募Keap1 E3连接酶序列的模块化纳米转运体引起的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）N蛋白的细胞内降解
Pharmaceutics. 2023 Dec 19;16(1):4. doi: 10.3390/pharmaceutics16010004.
8
An Extract Containing Nonvolatile Polyphenols Shows Virucidal Activity against SARS-CoV-2 That Is Enhanced in Increased pH Conditions.一种含有非挥发性多酚的提取物对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）具有杀病毒活性，在pH值升高的条件下这种活性会增强。
Pathogens. 2023 Aug 28;12(9):1093. doi: 10.3390/pathogens12091093.
9
Could veterinarians be immune to contracting SARS-CoV-2?兽医会对感染新型冠状病毒（SARS-CoV-2）具有免疫力吗？
Cent Eur J Immunol. 2022;47(3):275-279. doi: 10.5114/ceji.2022.119893. Epub 2022 Oct 4.
10
Among Antibody-Like Molecules, Monobodies, Able to Interact with Nucleocapsid Protein of SARS-CoV Virus, There Are Monobodies with High Affinity to Nucleocapsid Protein of SARS-CoV-2 Virus.在抗体样分子中，有一类单域抗体，能够与 SARS-CoV 病毒的核衣壳蛋白相互作用，其中有一些单域抗体对 SARS-CoV-2 病毒的核衣壳蛋白具有高亲和力。
Dokl Biochem Biophys. 2022 Apr;503(1):90-92. doi: 10.1134/S1607672922020077. Epub 2022 May 10.
本文引用的文献
1
Is COVID-19 receiving ADE from other coronaviruses?新冠病毒是否会从其他冠状病毒中获得增强效应？
Microbes Infect. 2020 Mar;22(2):72-73. doi: 10.1016/j.micinf.2020.02.006. Epub 2020 Feb 22.
2
Analysis of angiotensin-converting enzyme 2 (ACE2) from different species sheds some light on cross-species receptor usage of a novel coronavirus 2019-nCoV.对不同物种的血管紧张素转换酶2（ACE2）进行分析，有助于了解新型冠状病毒2019-nCoV的跨物种受体使用情况。
J Infect. 2020 Apr;80(4):469-496. doi: 10.1016/j.jinf.2020.02.013. Epub 2020 Feb 21.
3
First respiratory transmitted food borne outbreak?首例经呼吸道传播的食源性疾病暴发？
Int J Hyg Environ Health. 2020 May;226:113490. doi: 10.1016/j.ijheh.2020.113490. Epub 2020 Feb 20.
4
Presumed Asymptomatic Carrier Transmission of COVID-19.新冠病毒无症状感染者的传播。
JAMA. 2020 Apr 14;323(14):1406-1407. doi: 10.1001/jama.2020.2565.
5
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.新冠病毒的基因组特征和流行病学：对病毒起源和受体结合的影响。
Lancet. 2020 Feb 22;395(10224):565-574. doi: 10.1016/S0140-6736(20)30251-8. Epub 2020 Jan 30.
6
Emerging coronaviruses: Genome structure, replication, and pathogenesis.新兴冠状病毒：基因组结构、复制和发病机制。
J Med Virol. 2020 Apr;92(4):418-423. doi: 10.1002/jmv.25681. Epub 2020 Feb 7.
7
Cross-species transmission of the newly identified coronavirus 2019-nCoV.新型冠状病毒 2019-nCoV 的跨物种传播。
J Med Virol. 2020 Apr;92(4):433-440. doi: 10.1002/jmv.25682.
8
Canine Respiratory Coronavirus, Bovine Coronavirus, and Human Coronavirus OC43: Receptors and Attachment Factors.犬呼吸道冠状病毒、牛冠状病毒和人冠状病毒 OC43：受体和附着因子。
Viruses. 2019 Apr 5;11(4):328. doi: 10.3390/v11040328.
9
Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells.犬呼吸道冠状病毒利用 caveolin-1 介导的途径内化到 HRT-18G 细胞中。
Vet Res. 2018 Jul 3;49(1):55. doi: 10.1186/s13567-018-0551-9.
10
Antibody-dependent SARS coronavirus infection is mediated by antibodies against spike proteins.抗体依赖性 SARS 冠状病毒感染是由针对刺突蛋白的抗体介导的。
Biochem Biophys Res Commun. 2014 Aug 22;451(2):208-14. doi: 10.1016/j.bbrc.2014.07.090. Epub 2014 Jul 26.
Zotero 插件