Qu Zhibei, Shen Jianlei, Li Qian, Xu Feng, Wang Fei, Zhang Xueli, Fan Chunhai
Joint Research Center for Precision Medicine, Shanghai Jiao Tong University & Affiliated Sixth People's Hospital South Campus, Southern Medical University Affiliated Fengxian Hospital, Shanghai 201499, China.
School of Chemistry and Chemical Engineering, and Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
Theranostics. 2020 Feb 3;10(6):2631-2644. doi: 10.7150/thno.40808. eCollection 2020.
Intraoperative image-guided surgery (IGS) has attracted extensive research interests in determination of tumor margins from surrounding normal tissues. Introduction of near infrared (NIR) fluorophores into IGS could significantly improve the imaging quality thus benefit IGS. Among the reported NIR fluorophores, rare-earth nanoparticles exhibit unparalleled advantages in disease theranostics by taking advantages such as large Stokes shift, sharp emission spectra, and high chemical/photochemical stability. The recent advances in elements doping and morphologies controlling endow the rare-earth nanoparticles with intriguing optical properties, including emission span to NIR-II region and long life-time photoluminescence. Particularly, NIR emissive rare earth nanoparticles hold advantages in reduction of light scattering, photon absorption and autofluorescence, largely improve the performance of nanoparticles in biological and pre-clinical applications. In this review, we systematically compared the benefits of RE nanoparticles with other NIR probes, and summarized the recent advances of NIR emissive RE nanoparticles in bioimaging, photodynamic therapy, drug delivery and NIR fluorescent IGS. The future challenges and promises of NIR emissive RE nanoparticles for IGS were also discussed.
术中影像引导手术（IGS）在确定肿瘤与周围正常组织的边界方面引起了广泛的研究兴趣。将近红外（NIR）荧光团引入IGS可显著提高成像质量，从而使IGS受益。在已报道的NIR荧光团中，稀土纳米颗粒通过利用诸如大斯托克斯位移、尖锐发射光谱和高化学/光化学稳定性等优势，在疾病诊疗中展现出无与伦比的优势。元素掺杂和形貌控制方面的最新进展赋予了稀土纳米颗粒引人入胜的光学特性，包括发射光谱延伸至近红外二区（NIR-II）以及长寿命光致发光。特别地，近红外发射稀土纳米颗粒在减少光散射、光子吸收和自发荧光方面具有优势，极大地提升了纳米颗粒在生物和临床前应用中的性能。在本综述中，我们系统地比较了稀土纳米颗粒与其他近红外探针的优势，并总结了近红外发射稀土纳米颗粒在生物成像、光动力疗法、药物递送和近红外荧光IGS方面的最新进展。还讨论了近红外发射稀土纳米颗粒用于IGS的未来挑战和前景。
