State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
College of Materials, Xiamen University, Xiamen, 361005, China.
Angew Chem Int Ed Engl. 2020 Jun 15;59(25):9914-9921. doi: 10.1002/anie.201908712. Epub 2019 Sep 5.
The use of gold nanoparticles as radiosensitizers is an effective way to boost the killing efficacy of radiotherapy while drastically limiting the received dose and reducing the possible damage to normal tissues. Herein, we designed aggregation-induced emission gold clustoluminogens (AIE-Au) to achieve efficient low-dose X-ray-induced photodynamic therapy (X-PDT) with negligible side effects. The aggregates of glutathione-protected gold clusters (GCs) assembled through a cationic polymer enhanced the X-ray-excited luminescence by 5.2-fold. Under low-dose X-ray irradiation, AIE-Au strongly absorbed X-rays and efficiently generated hydroxyl radicals, which enhanced the radiotherapy effect. Additionally, X-ray-induced luminescence excited the conjugated photosensitizers, resulting in a PDT effect. The in vitro and in vivo experiments demonstrated that AIE-Au effectively triggered the generation of reactive oxygen species with an order-of-magnitude reduction in the X-ray dose, enabling highly effective cancer treatment.
金纳米粒子作为放射增敏剂的应用是一种有效的方法，可以在大大限制接受剂量和减少对正常组织可能造成的损伤的同时，提高放射治疗的杀伤效果。在此，我们设计了聚集诱导发射金纳米团簇（AIE-Au），以实现高效的低剂量 X 射线诱导光动力治疗（X-PDT），几乎没有副作用。通过阳离子聚合物组装的谷胱甘肽保护的金纳米团簇（GCs）的聚集体使 X 射线激发的发光增强了 5.2 倍。在低剂量 X 射线照射下，AIE-Au 强烈吸收 X 射线并有效地产生羟基自由基，增强了放射治疗效果。此外，X 射线激发的发光激发了共轭光敏剂，产生光动力治疗效应。体外和体内实验表明，AIE-Au 可以有效地触发活性氧的产生，X 射线剂量降低了一个数量级，从而实现了高效的癌症治疗。
