State Key Laboratory of Bioelectronics, National Demonstration Center for Experimental Biomedical Engineering Education, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
Hunan Key Laboratory of Biological Nanomaterials and Devices, College of life sciences and chemistry, Hunan University of Technology, Zhuzhou 412007, Hunan, China.
Theranostics. 2020 Feb 10;10(7):3206-3222. doi: 10.7150/thno.40414. eCollection 2020.
With the rapid development of nanotechnology, inorganic nanomaterials (NMs) have been widely applied in modern society. As human exposure to inorganic NMs is inevitable, comprehensive assessment of the safety of inorganic NMs is required. It is well known that autophagy plays dual roles in cell survival and cell death. Moreover, inorganic NMs have been proven to induce autophagy perturbation in cells. Therefore, an in-depth understanding of inorganic NMs-modulated autophagy is required for the safety assessment of inorganic NMs. This review presents an overview of a set of inorganic NMs, consisting of iron oxide NMs, silver NMs, gold NMs, carbon-based NMs, silica NMs, quantum dots, rare earth oxide NMs, zinc oxide NMs, alumina NMs, and titanium dioxide NMs, as well as how each modulates autophagy. This review emphasizes the potential mechanisms underlying NMs-induced autophagy perturbation, as well as the role of autophagy perturbation in cell fate determination. Furthermore, we also briefly review the potential roles of inorganic NMs-modulated autophagy in diagnosis and treatment of disease.
随着纳米技术的飞速发展，无机纳米材料（NMs）已广泛应用于现代社会。由于人类不可避免地会接触到无机纳米材料，因此需要对其安全性进行全面评估。众所周知，自噬在细胞存活和细胞死亡中发挥双重作用。此外，已经证明无机纳米材料会诱导细胞自噬失调。因此，为了对无机纳米材料的安全性进行评估，需要深入了解无机纳米材料调节的自噬作用。本综述概述了一组无机纳米材料，包括氧化铁纳米材料、银纳米材料、金纳米材料、碳基纳米材料、硅纳米材料、量子点、稀土氧化物纳米材料、氧化锌纳米材料、氧化铝纳米材料和二氧化钛纳米材料，以及它们各自如何调节自噬作用。本综述强调了纳米材料诱导自噬失调的潜在机制，以及自噬失调在细胞命运决定中的作用。此外，我们还简要综述了无机纳米材料调节的自噬在疾病诊断和治疗中的潜在作用。
