调控叶片身份，独立于 miR156 介导的翻译抑制。
regulates leaf identity independently of miR156-mediated translational repression.
机构信息
Biology Department, University of Pennsylvania, 433 S. University Ave, Philadelphia, PA 19104, USA.
Biology Department, University of Pennsylvania, 433 S. University Ave, Philadelphia, PA 19104, USA
出版信息
Development. 2020 Apr 27;147(8):dev186874. doi: 10.1242/dev.186874.
In , loss of the carboxypeptidase ALTERED MERISTEM PROGRAM1 (AMP1) produces an increase in the rate of leaf initiation, an enlarged shoot apical meristem and an increase in the number of juvenile leaves. This phenotype is also observed in plants with reduced levels of miR156-targeted () transcription factors, suggesting that AMP1 might promote SPL activity. However, we found that the mutant phenotype is only partially corrected by elevated gene expression, and that has no significant effect on transcript levels, or on the level or the activity of miR156. Although AMP1 has been reported to promote miRNA-mediated translational repression, did not prevent the translational repression of the miR156 target or the miR159 target These results suggest that regulates vegetative phase change downstream of, or in parallel to, the miR156/ pathway, and that it is not universally required for miRNA-mediated translational repression.
在拟南芥中，羧肽酶 ALTERED MERISTEM PROGRAM1（AMP1）的缺失会导致叶片起始率增加、茎尖分生组织增大以及幼叶数量增加。这种表型也存在于 miR156 靶向的（）转录因子水平降低的植物中，这表明 AMP1 可能促进 SPL 活性。然而，我们发现，突变体表型仅部分通过升高基因表达得到纠正，并且对转录水平，或对 miR156 的水平或活性没有显著影响。尽管 AMP1 已被报道可促进 miRNA 介导的翻译抑制，但它并未阻止 miR156 靶标或 miR159 靶标 的翻译抑制。这些结果表明，在 miR156/途径下游或平行于 miR156/途径调节营养阶段转变，并且它不是 miRNA 介导的翻译抑制所普遍需要的。
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