Laboratory of Microbial Pathogenesis, Navarrabiomed, Complejo Hospitalario de Navarra (CHN)-Universidad Pública de Navarra (UPNA), IDISNA, Pamplona, 31008, Spain.
Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.
Curr Opin Microbiol. 2020 Jun;55:40-47. doi: 10.1016/j.mib.2020.02.004. Epub 2020 Mar 19.
Bacteria use two-component systems (TCSs) to sense and respond to their environments. Free-living bacteria usually contain dozens of TCSs, each of them responsible for sensing and responding to a different range of signals. Differences in the content of two-component systems are related with the capacity of the bacteria to colonize different niches or improve the efficiency to grow under the conditions of the existing niche. This review highlights differences in the TCS content between Staphylococcus aureus and Staphylococcus saprophyticus as a case study to exemplify how the ability to sense and respond to the environment is relevant for bacterial capacity to colonize and survive in/on different body surfaces.
细菌利用双组分系统 (TCS) 来感知和响应其环境。自由生活的细菌通常包含数十个 TCS，每个 TCS 负责感知和响应不同范围的信号。双组分系统含量的差异与细菌在不同小生境中定植的能力或在现有小生境条件下提高生长效率有关。本综述以金黄色葡萄球菌和腐生葡萄球菌之间的 TCS 含量差异为例，强调了细菌感知和响应环境的能力与其在不同体表定植和存活的能力相关。
