Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark/The Danish Multiple Sclerosis Registry, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Mult Scler. 2021 Feb;27(2):188-197. doi: 10.1177/1352458520912500. Epub 2020 Mar 23.
Environmental factors are associated with acquiring multiple sclerosis (MS) particularly in adolescence.
To test for association between MS and exposure to passive smoking at the age of 10-19.
A total of 919 patients from the Danish MS Registry and Biobank and 3419 healthy blood donors who had not smoked before the age of 19 were targeted. We analyzed separately for each sex and for those never-smokers (cohort 1) and active smokers above the age of 19 (cohort 2). All participants completed standardized questionnaires about smoking and lifestyle. We matched cases and controls in the ratio of 1:2 by propensity scores discarding unmatchable individuals and used logistic regression adjusted for all covariates and interactions.
After matching, we included 110/213 male cases/controls and 232/377 female case/controls in cohort 1. In cohort 2, the numbers were 160/320 and 417/760, respectively. Among women in cohort 1, the odds ratio (OR) for MS by passive smoking at the age of 10-19 was 1.432 ( = 0.037) but in men it was 1.232 ( = 0.39). Among men in cohort 2, OR was 1.593 ( = 0.022) but among women it was only 1.102 ( = 0.44).
Among never smokers, female MS cases were more often than female controls reported with passive smoking between the age of 10 and 19, and among smokers above the age of 19, male MS patients were more often than male controls reported with passive smoking.
环境因素与多发性硬化症（MS）的发病有关，尤其是在青少年时期。
检测 10-19 岁时被动吸烟与多发性硬化症之间的相关性。
本研究共纳入 919 名来自丹麦多发性硬化症注册和生物库的患者和 3419 名 19 岁前从未吸烟的健康献血者。我们分别对男性和女性以及从未吸烟（队列 1）和 19 岁以上吸烟的人群（队列 2）进行分析。所有参与者均完成了关于吸烟和生活方式的标准化问卷。我们通过倾向评分匹配病例和对照，比例为 1:2，并丢弃无法匹配的个体，然后使用调整所有协变量和交互作用的逻辑回归进行分析。
匹配后，我们纳入队列 1 中的 110/213 名男性病例/对照和 232/377 名女性病例/对照，队列 2 中的人数分别为 160/320 和 417/760。在队列 1 的女性中，10-19 岁时被动吸烟与多发性硬化症的比值比（OR）为 1.432（ = 0.037），但在男性中为 1.232（ = 0.39）。在队列 2 的男性中，OR 为 1.593（ = 0.022），而在女性中仅为 1.102（ = 0.44）。
在从未吸烟者中，与对照组相比，更多的女性多发性硬化症病例报告在 10 至 19 岁之间有被动吸烟史，而在 19 岁以上的吸烟者中，与对照组相比，更多的男性多发性硬化症患者报告有被动吸烟史。
