Fabrication of bacterial cellulose-based wound dressings with improved performance by impregnation with alginate.

Bacterial cellulose (BC) hydrogels are among the most efficient materials already being used for the treatment of complex wounds. The moist environment provided by the BC dressing is a key feature assuring efficient wound recovery. Improving the dressings´ moisture-holding ability facilitates its application and leads to an economically preferable extended wear time. To produce materials with reduced moisture loss, BC dressings were impregnated with a secondary hydrophilic component: alginate. The feasibility of an industrial fabrication of this composite was evaluated on pilot scale equipment. It was shown that the procedure can easily be scaled up without significantly increasing the manufacturing time. The resultant composite possessed improved water-retention properties, providing a smooth dressing exchange as demonstrated by a wound-imitating model. The new materials were moreover shown to be compatible with an antimicrobially active compound, which assures their efficiency in the treatment of highly colonized wounds.