University of Natural Resources and Life Sciences, Vienna (BOKU University), Department of Chemistry, Institute for Chemistry of Renewable Resources, Konrad-Lorenz-Strasse 24, 3430 Tulln, Austria.
Lohmann & Rauscher GmbH & Co. KG, Irlicher Strasse 55, 56567 Neuwied, Germany.
Mater Sci Eng C Mater Biol Appl. 2020 May;110:110619. doi: 10.1016/j.msec.2019.110619. Epub 2020 Jan 7.
Bacterial cellulose (BC) hydrogels are among the most efficient materials already being used for the treatment of complex wounds. The moist environment provided by the BC dressing is a key feature assuring efficient wound recovery. Improving the dressings´ moisture-holding ability facilitates its application and leads to an economically preferable extended wear time. To produce materials with reduced moisture loss, BC dressings were impregnated with a secondary hydrophilic component: alginate. The feasibility of an industrial fabrication of this composite was evaluated on pilot scale equipment. It was shown that the procedure can easily be scaled up without significantly increasing the manufacturing time. The resultant composite possessed improved water-retention properties, providing a smooth dressing exchange as demonstrated by a wound-imitating model. The new materials were moreover shown to be compatible with an antimicrobially active compound, which assures their efficiency in the treatment of highly colonized wounds.
细菌纤维素 (BC) 水凝胶是目前用于治疗复杂伤口的最有效材料之一。BC 敷料提供的湿润环境是确保伤口有效恢复的关键特征。提高敷料的保水能力有助于其应用，并延长了经济上更可取的佩戴时间。为了生产减少水分流失的材料，将 BC 敷料浸渍在二次亲水成分：海藻酸钠中。在中试设备上评估了这种复合材料的工业化制造的可行性。结果表明，该方法可以很容易地放大，而不会显著增加制造时间。所得的复合材料具有改善的保水性能，提供了一个平滑的敷料更换，如模仿伤口的模型所证明的那样。此外，这些新材料还与具有抗菌活性的化合物相容，这确保了它们在治疗高度定植伤口方面的效率。
