Laskus T, Lupa E, Szczutowska E, Babiuch L
Department of Immunopathology, Institute of Infectious Diseases, Wolska, Poland.
Infection. 1988;16(6):354-7. doi: 10.1007/BF01644546.
124 consecutive patients (mean age: 41.1 years; range: 20-63 years) attending an outpatient alcoholic clinic were tested for the presence of markers of HBV infection. HBsAg was found in 26 (21%), anti-HBs and/or anti-HBc in the absence of HBsAg in 35 (28%). Altogether, at least one marker was present in 61 (49%), these results being significantly higher than in a matched control population. In 70 cases HBV status was compared with epidemiological data. No relationship was found with past blood transfusions, hospitalization or jaundice. HBV infection was, however, more common when parents of the subjects were alcoholics, which points to a possible role of family spreading. Furthermore, chronic infection with HBV was related to high alcohol intake.
124名连续就诊于门诊酒精诊所的患者(平均年龄:41.1岁;范围:20 - 63岁)接受了乙肝病毒(HBV)感染标志物检测。26名患者(21%)检测出乙肝表面抗原(HBsAg)阳性,35名患者(28%)在无HBsAg的情况下检测出乙肝表面抗体(抗-HBs)和/或乙肝核心抗体(抗-HBc)阳性。总体而言,61名患者(49%)至少存在一种标志物阳性,这些结果显著高于匹配的对照人群。在70例患者中,将HBV感染状况与流行病学数据进行了比较。未发现与既往输血、住院或黄疸之间存在关联。然而,当受试者的父母为酗酒者时,HBV感染更为常见,这表明家庭传播可能起到了一定作用。此外,HBV慢性感染与高酒精摄入量有关。