Metabolites Produced by the Oral Commensal Bacterium Extend the Lifespan of via SIR-2.1 Overexpression.

Human microbiota is heavily involved in host health, including the aging process. Based on the hypothesis that the human microbiota manipulates host aging via the production of chemical messengers, lifespan-extending activities of the metabolites produced by the oral commensal bacterium and derivatives thereof were evaluated using the model organism . Chemical investigation of the acetone extract of a culture led to the identification of monoamines and -acetyl monoamines as major metabolites. Phenethylamine and -acetylphenethylamine induced a potent and dose-dependent increase of the lifespan, up to 21.6% and 19.9%, respectively. A mechanistic study revealed that the induction of SIR-2.1, a highly conserved protein associated with the regulation of lifespan, was responsible for the observed increased longevity.