Huang Wei, Wang Sibao, Jacobs-Lorena Marcelo
Department of Molecular Microbiology and Immunology, Johns Hopkins Malaria Research Institute, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
CAS Key Laboratory of Insect Developmental and Evolutionary Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Front Genet. 2020 Mar 10;11:196. doi: 10.3389/fgene.2020.00196. eCollection 2020.
Mosquito-borne diseases cause more than 700 million people infected and one million people die (Caraballo and King, 2014). With the limitations of progress toward elimination imposed by insecticide- and drug-resistance, combined with the lack of vaccines, innovative strategies to fight mosquito-borne disease are urgently needed. In recent years, the use of mosquito microbiota has shown great potential for cutting down transmission of mosquito-borne pathogens. Here we review what is known about the mosquito microbiota and how this knowledge is being used to develop new ways to control mosquito-borne disease. We also discuss the challenges for the eventual release of genetically modified (GM) symbionts in the field.
蚊媒疾病导致超过7亿人感染，100万人死亡（卡拉巴洛和金，2014年）。由于杀虫剂和药物抗性对疾病消除进程造成限制，再加上缺乏疫苗，迫切需要创新策略来对抗蚊媒疾病。近年来，利用蚊子微生物群在减少蚊媒病原体传播方面显示出巨大潜力。在此，我们综述了关于蚊子微生物群的已知信息，以及这些知识如何被用于开发控制蚊媒疾病的新方法。我们还讨论了在野外最终释放转基因共生体所面临的挑战。
