Burlakovskiy M S, Yemelyanov V V, Lutova L A
Biology Faculty, St. Petersburg State University, St. Petersburg, 199034 Russia.
Appl Biochem Microbiol. 2016;52(2):121-137. doi: 10.1134/S0003683816020034. Epub 2016 Mar 31.
Cytokines are a family of signaling polypeptides involved in intercellular interactions in the process of the immune response, as well as in the regulation of a number of normal physiological functions. Cytokines are used in medicine for the treatment of cancer, immune disorders, viral infections, and other socially significant diseases, but the extent of their use is limited by the high production cost of the active agent. The development of this area of pharmacology is associated with the success of genetic engineering, which allows the production of significant amounts of protein by transgenic organisms. The review discusses the latest advances in the production of various cytokines with the use of genetically modified plants.
细胞因子是一类信号多肽家族，参与免疫反应过程中的细胞间相互作用以及多种正常生理功能的调节。细胞因子在医学上用于治疗癌症、免疫紊乱、病毒感染和其他具有社会意义的疾病，但其使用范围受到活性剂高生产成本的限制。药理学这一领域的发展与基因工程的成功相关，基因工程使转基因生物能够大量生产蛋白质。本文综述了利用转基因植物生产各种细胞因子的最新进展。
