Sirko Agnieszka, Vaněk Tomas, Góra-Sochacka Anna, Redkiewicz Patrycja
Institute of Biochemistry and Biophysics Polish Academy of Sciences, ul. Pawinskiego 5a, 02-106 Warsaw, Poland; E-Mails:
Int J Mol Sci. 2011;12(6):3536-52. doi: 10.3390/ijms12063536. Epub 2011 Jun 3.
Plant-based platforms have been successfully applied for the last two decades for the efficient production of pharmaceutical proteins. The number of commercialized products biomanufactured in plants is, however, rather discouraging. Cytokines are small glycosylated polypeptides used in the treatment of cancer, immune disorders and various other related diseases. Because the clinical use of cytokines is limited by high production costs they are good candidates for plant-made pharmaceuticals. Several research groups explored the possibilities of cost-effective production of animal cytokines in plant systems. This review summarizes recent advances in this field.
在过去二十年中，基于植物的平台已成功应用于高效生产药用蛋白质。然而，在植物中生物制造的商业化产品数量却相当令人沮丧。细胞因子是用于治疗癌症、免疫紊乱和各种其他相关疾病的小糖基化多肽。由于细胞因子的临床应用受到高生产成本的限制，它们是植物制造药物的良好候选者。几个研究小组探索了在植物系统中经济高效地生产动物细胞因子的可能性。本综述总结了该领域的最新进展。
