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关于对大林羚进行狂犬病口服疫苗接种的诱饵研究。

Baiting studies on oral vaccination of the greater kudu () against rabies.

作者信息

Hassel Rainer, Ortmann Steffen, Clausen Peter, Jago Mark, Bruwer Floris, Lindeque Pauline, Freuling Conrad, Vos Ad, Müller Thomas

机构信息

1School of Veterinary Medicine, University of Namibia, Private Bag 13301, Windhoek, Namibia.

2IDT Biologika GmbH, Am Pharmapark, 06861 Dessau-Rosslau, Germany.

出版信息

Eur J Wildl Res. 2018;64(6):62. doi: 10.1007/s10344-018-1220-z. Epub 2018 Oct 9.

Abstract

Rabies in the greater kudu (), one of the largest African antelopes, is a phenomenon unique to Namibia. Since the mid-1970s, the country has been plagued by two epizootics that claimed thousands of casualties among the indigenous kudu population. Reasons as to why kudus appear to be exceptionally susceptible to the disease still remain speculative at best. Because the Namibian economy relies heavily on trophy hunting, game meat hunting, and ecotourism, the current severe spread of rabies among kudus calls for effective measures to protect these antelopes. Oral vaccination of kudus may offer a possibility provided efficacious oral rabies vaccines are available. In this screening study, we explored options for attractive baits that facilitate optimal vaccine uptake by the target species and a bait distribution system that maximizes bait availability to the target species meanwhile minimizing bait depletion by non-target species. The results show that gelatin-based baits mixed with local (pods of the camel thorn tree) but also imported (apple-flavored corn meal) attractants are highly attractive for kudus providing a basis for future oral rabies vaccine baits.

摘要

大羚羊(非洲最大的羚羊之一)感染狂犬病是纳米比亚特有的现象。自20世纪70年代中期以来,该国一直受到两次动物疫病流行的困扰,导致当地大羚羊种群中有数千只死亡。至于大羚羊为何似乎对这种疾病异常易感,目前最多也只是推测。由于纳米比亚经济严重依赖战利品狩猎、野味狩猎和生态旅游,目前狂犬病在大羚羊中的严重传播需要采取有效措施来保护这些羚羊。如果有有效的口服狂犬病疫苗,对大羚羊进行口服疫苗接种可能是一种选择。在这项筛选研究中,我们探索了制作有吸引力诱饵的方法,以促进目标物种对疫苗的最佳摄取,并建立一个诱饵分发系统,使目标物种能最大限度地获取诱饵,同时尽量减少非目标物种对诱饵的消耗。结果表明,混合了当地(骆驼刺树的豆荚)和进口(苹果味玉米粉)引诱剂的明胶基诱饵对大羚羊极具吸引力,为未来的口服狂犬病疫苗诱饵提供了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2239/7088030/c23f88702ae6/10344_2018_1220_Fig1_HTML.jpg

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