内毒素诱导的控制骨髓源性淋巴细胞分化的血清因子。
Endotoxin-induced serum factor controlling differentiation of bone-marrow-derived lymphocytes.
作者信息
Hoffmann M K, Oettgen H F, Old L J, Chin A F, Hammerling U
出版信息
Proc Natl Acad Sci U S A. 1977 Mar;74(3):1200-3. doi: 10.1073/pnas.74.3.1200.
Serum from bacillus Calmette-Guerin-infected mice injected with endotoxin induces the appearance of surface immunoglobulin, Ia antigen, and complement receptor on the surface of precursor bone-marrow-derived (B) cells. While endotoxin itself causes phenotypic conversion of both thymus-derived (T) cells and B cells in vitro, the endotoxin-induced serum factor was found to be a selective inducer of B cell differentiation. Spleen cells rendered immunodeficient by removal of B cells bearing the complement receptor regained the capacity to cooperate with helper T cells and to produce antibody against red cell antigens in vitro upon upon addition of the serum factor to the culture medium. Thus, a factor that controls selective phenotypic and functional differentiation of B cells has been identified and can now be characterized,
用内毒素注射卡介苗感染小鼠后获得的血清，可诱导前体骨髓来源（B）细胞表面出现表面免疫球蛋白、Ia抗原和补体受体。虽然内毒素本身在体外可引起胸腺来源（T）细胞和B细胞的表型转化，但发现内毒素诱导的血清因子是B细胞分化的选择性诱导剂。通过去除带有补体受体的B细胞而导致免疫缺陷的脾细胞，在向培养基中添加血清因子后，恢复了与辅助性T细胞协同作用并在体外产生针对红细胞抗原抗体的能力。因此，一种控制B细胞选择性表型和功能分化的因子已被鉴定出来，现在可以对其进行特性分析。
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